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Figure 5 | BMC Cancer

Figure 5

From: Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

Figure 5

Commonly CD133+ cell up-regulated genes participate in angiogenesis, tumour development and neural developmental disorders. Ingenuity representation and classification by functions of those common up-regulated genes in all CD133+ vs. CD133- cell GBM samples. Red colour genes are the most positive deregulated and grey one those with a lower over-expression levels in this group. The first cluster of genes (COL1A1, COL1A2, TGFB1...) has been described largely in angiogenesis and permeability whereas the second cluster (LRRFIP1 and OPHN1) participates in developmental disorders. Changing transcription pattern of all of them favour tumour development.

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