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Figure 4 | BMC Cancer

Figure 4

From: Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

Figure 4

Leptin is mitogenic for HCC cells. (a) Effect of leptin on HepG2 cell proliferation. Cell number is expressed as percentage of control, i.e. cell cultures that was untreated. Columns, mean of three independent experiments done in triplicate; bars, SD, *, p < 0.001 compared to untreated cells (for siRNA experiment compared to siRNA control), (b) Leptin icreased the fraction of HepG2 cells in S and G2/M phases of the cycle. HepG2 cells were exposed to leptin (50, 200 ng/ml for 48 h and 100 ng/ml for to 2 months) and leptin siRNA. Columns, mean of three independent experiments done in triplicate; bars, SD, *, p < 0.05 compared to untreated cells (for siRNA experiment compared to siRNA control).

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