| Condition | DEF | CI | ID50 | SF2 | % survival | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | mean | SD |  | mean | SD |  | mean | SD |  | mean | SD |  | mean | SD |  |
CAL-27 | RT | Â | Â | Â | Â | Â | Â | 1.94 | 0.47 | Â | 48.37 | 9.31 | Â | 100% | 0% | Â |
 | 24 h 50 nM MTA → RT | 1.04 | 0.23 |  | 1.095 | 0.127 |  | 1.97 | 0.45 |  | 49.25 | 9.71 |  | 97% | 11% |  |
 | 24 h 50 nM MTA → 24 h → RT | 1.59 | 0.53 |  | 0.916 | 0.063 |  | 1.71 | 0.66 |  | 43.37 | 12.35 |  | 70% | 21% |  |
 | 24 h 50 nM MTA → 1 h → RT | 1.46 | 0.21 |  | 0.933 | 0.073 |  | 1.21 | 0.35 |  | 32.45 | 8.43 |  | 98% | 4% |  |
 | 24 h 2 nM dFdC → RT | 1.47 | 0.09 |  | 0.888 | 0.180 | * | 1.72 | 0.10 |  | 49.25 | 9.71 |  | 96% | 1% |  |
 | 24 h 2 nM dFdC → 24 h → RT | 1.04 | 0.16 |  | 1.090 | 0.101 |  | 2.43 | 0.08 |  | 58.31 | 2.96 |  | 84% | 18% |  |
 | 1 h 100 nM dFdC → 24 h → RT | 1.56 | 0.46 |  | 0.653 | 0.108 | ** | 1.32 | 0.25 |  | 34.09 | 5.34 |  | 91% | 24% |  |
 | 1 h 50 nM dFdC → RT | 1.07 | 0.19 |  | 0.917 | 0.124 |  | 1.69 | 0.64 |  | 44.73 | 14.77 |  | 98% | 14% |  |
 | 24 h 2 nM dFdC + 24 h 50 nM MTA → RT | 1.53 | 0.27 | †| 0.960 | 0.267 |  | 1.66 | 0.09 |  | 42.27 | 1.03 |  | 98% | 11% |  |
 | 24 h 2 nM dFdC → 24 h 50 nM MTA → RT | 1.38 | 0.09 |  | 0.949 | 0.106 |  | 1.85 | 0.34 |  | 46.93 | 6.81 |  | 75% | 4% | †|
 | 24 h 50 nM MTA → 24 h 2 nM dFdC → RT | 1.78 | 0.14 |  | 0.705 | 0.097 | * | 1.42 | 0.06 |  | 36.83 | 3.36 |  | 64% | 22% |  |
 | 1 h 100 nM dFdC → 24 h 50 nM MTA → RT | 1.56 | 0.37 | †| 0.801 | 0.094 | * | 1.29 | 0.20 | †| 34.65 | 4.07 | †| 71% | 15% | †|
 | 24 h 50 nM MTA → 1 h 50 nM dFdC → RT | 1.43 | 0.57 |  | 0.858 | 0.175 | * | 1.30 | 0.45 |  | 34.93 | 10.25 |  | 65% | 11% | †;††|
A549 | RT | Â | Â | Â | Â | Â | Â | 2.41 | 0.39 | Â | 56.26 | 6.18 | Â | 100% | 0% | Â |
 | 24 h 100 nM MTA → RT | 1.29 | 0.25 |  | 0.674 | 0.053 | ** | 1.77 | 0.36 |  | 45.39 | 7.15 |  | 87% | 11% |  |
 | 24 h 100 nM MTA → 24 h → RT | 0.98 | 0.15 |  | 0.838 | 0.070 | * | 2.16 | 0.11 |  | 52.70 | 2.00 |  | 84% | 16% |  |
 | 24 h 100 nM MTA → 1 h → RT | 1.52 | 0.39 |  | 0.681 | 0.084 | ** | 1.85 | 0.51 |  | 46.28 | 9.78 |  | 85% | 11% |  |
 | 24 h 2 nM dFdC → RT | 1.55 | 0.24 |  | 0.538 | 0.057 | ** | 1.25 | 0.08 |  | 34.55 | 2.01 |  | 71% | 16% |  |
 | 24 h 2 nM dFdC → 24 h → RT | 0.99 | 0.31 |  | 0.703 | 0.118 | * | 2.04 | 0.40 |  | 50.19 | 6.96 |  | 65% | 4% |  |
 | 1 h 100 nM dFdC → 24 h → RT | 1.23 | 0.23 |  | 0.606 | 0.073 | ** | 1.97 | 0.24 |  | 49.28 | 4.36 |  | 67% | 13% |  |
 | 1 h 50 nM dFdC → RT | 1.49 | 0.39 |  | 0.831 | 0.068 | * | 1.92 | 0.49 |  | 47.99 | 8.72 |  | 96% | 5% |  |
 | 24 h 2 nM dFdC + 24 h 100 nM MTA → RT | 1.49 | 0.28 |  | 0.564 | 0.075 | ** | 1.32 | 0.30 |  | 36.11 | 6.47 |  | 66% | 23% |  |
 | 24 h 2 nM dFdC → 24 h 100 nM MTA → RT | 0.94 | 0.27 |  | 0.585 | 0.101 | ** | 2.21 | 0.80 |  | 52.39 | 11.98 |  | 47% | 14% |  |
 | 24 h 100 nM MTA → 24 h 2 nM dFdC → RT | 1.17 | 0.24 |  | 0.500 | 0.073 | ** | 1.69 | 0.36 |  | 44.34 | 7.16 |  | 48% | 16% | †|
 | 1 h 100 nM dFdC → 24 h 100 nM MTA → RT | 1.29 | 0.27 |  | 0.513 | 0.053 | ** | 1.88 | 0.25 |  | 47.68 | 4.45 |  | 48% | 12% | †|
 | 24 h 100 nM MTA → 1 h 50 nM dFdC → RT | 1.52 | 0.58 |  | 0.534 | 0.083 | ** | 1.92 | 0.50 |  | 47.93 | 9.71 |  | 49% | 8% | †;††|