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Table 4 DEF, CI, ID50, SF2 and % survival (representing the cytotoxic effect of treatment with MTA and/or dFdC alone, 0 Gy) for MTA - dFdC - irradiation (RT) combinations in CAL-27 and A549 cells.

From: In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

 

Condition

DEF

CI

ID50

SF2

% survival

  

mean

SD

 

mean

SD

 

mean

SD

 

mean

SD

 

mean

SD

 

CAL-27

RT

      

1.94

0.47

 

48.37

9.31

 

100%

0%

 
 

24 h 50 nM MTA → RT

1.04

0.23

 

1.095

0.127

 

1.97

0.45

 

49.25

9.71

 

97%

11%

 
 

24 h 50 nM MTA → 24 h → RT

1.59

0.53

 

0.916

0.063

 

1.71

0.66

 

43.37

12.35

 

70%

21%

 
 

24 h 50 nM MTA → 1 h → RT

1.46

0.21

 

0.933

0.073

 

1.21

0.35

 

32.45

8.43

 

98%

4%

 
 

24 h 2 nM dFdC → RT

1.47

0.09

 

0.888

0.180

*

1.72

0.10

 

49.25

9.71

 

96%

1%

 
 

24 h 2 nM dFdC → 24 h → RT

1.04

0.16

 

1.090

0.101

 

2.43

0.08

 

58.31

2.96

 

84%

18%

 
 

1 h 100 nM dFdC → 24 h → RT

1.56

0.46

 

0.653

0.108

**

1.32

0.25

 

34.09

5.34

 

91%

24%

 
 

1 h 50 nM dFdC → RT

1.07

0.19

 

0.917

0.124

 

1.69

0.64

 

44.73

14.77

 

98%

14%

 
 

24 h 2 nM dFdC + 24 h 50 nM MTA → RT

1.53

0.27

†

0.960

0.267

 

1.66

0.09

 

42.27

1.03

 

98%

11%

 
 

24 h 2 nM dFdC → 24 h 50 nM MTA → RT

1.38

0.09

 

0.949

0.106

 

1.85

0.34

 

46.93

6.81

 

75%

4%

†

 

24 h 50 nM MTA → 24 h 2 nM dFdC → RT

1.78

0.14

 

0.705

0.097

*

1.42

0.06

 

36.83

3.36

 

64%

22%

 
 

1 h 100 nM dFdC → 24 h 50 nM MTA → RT

1.56

0.37

†

0.801

0.094

*

1.29

0.20

†

34.65

4.07

†

71%

15%

†

 

24 h 50 nM MTA → 1 h 50 nM dFdC → RT

1.43

0.57

 

0.858

0.175

*

1.30

0.45

 

34.93

10.25

 

65%

11%

†;††

A549

RT

      

2.41

0.39

 

56.26

6.18

 

100%

0%

 
 

24 h 100 nM MTA → RT

1.29

0.25

 

0.674

0.053

**

1.77

0.36

 

45.39

7.15

 

87%

11%

 
 

24 h 100 nM MTA → 24 h → RT

0.98

0.15

 

0.838

0.070

*

2.16

0.11

 

52.70

2.00

 

84%

16%

 
 

24 h 100 nM MTA → 1 h → RT

1.52

0.39

 

0.681

0.084

**

1.85

0.51

 

46.28

9.78

 

85%

11%

 
 

24 h 2 nM dFdC → RT

1.55

0.24

 

0.538

0.057

**

1.25

0.08

 

34.55

2.01

 

71%

16%

 
 

24 h 2 nM dFdC → 24 h → RT

0.99

0.31

 

0.703

0.118

*

2.04

0.40

 

50.19

6.96

 

65%

4%

 
 

1 h 100 nM dFdC → 24 h → RT

1.23

0.23

 

0.606

0.073

**

1.97

0.24

 

49.28

4.36

 

67%

13%

 
 

1 h 50 nM dFdC → RT

1.49

0.39

 

0.831

0.068

*

1.92

0.49

 

47.99

8.72

 

96%

5%

 
 

24 h 2 nM dFdC + 24 h 100 nM MTA → RT

1.49

0.28

 

0.564

0.075

**

1.32

0.30

 

36.11

6.47

 

66%

23%

 
 

24 h 2 nM dFdC → 24 h 100 nM MTA → RT

0.94

0.27

 

0.585

0.101

**

2.21

0.80

 

52.39

11.98

 

47%

14%

 
 

24 h 100 nM MTA → 24 h 2 nM dFdC → RT

1.17

0.24

 

0.500

0.073

**

1.69

0.36

 

44.34

7.16

 

48%

16%

†

 

1 h 100 nM dFdC → 24 h 100 nM MTA → RT

1.29

0.27

 

0.513

0.053

**

1.88

0.25

 

47.68

4.45

 

48%

12%

†

 

24 h 100 nM MTA → 1 h 50 nM dFdC → RT

1.52

0.58

 

0.534

0.083

**

1.92

0.50

 

47.93

9.71

 

49%

8%

†;††

  1. †: p < 0.05 vs. corresponding schedule of MTA and RT; ††: p < 0.05 vs. corresponding schedule of dFdC and RT; *: moderate synergism (0.7<CI<0.9); **: synergism (CI<0.7).