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Table 3 IC50 and combination index (CI) values for MTA - dFdC combinations in CAL-27 and A549 cells.

From: In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

Condition CAL-27 A549
  IC50(nM) SD   CI SD     IC50(nM) SD   CI SD  
24 h MTA → 24 h wash out 118.53 16.37        569.47 120.60     
24 h wash out → 24 h MTA 198.25 14.51        1576.86 349.19     
24 h MTA + 24 h 2 nM dFdC → 24 h wash out 147.44 18.68   1.038 0.378     1689.43 1289.82   1.003 0.352  
24 h MTA + 24 h 4 nM dFdC → 24 h wash out 240.31 49.10 0.957 0.510     9120.46 1499.06 0.569 0.271 **
24 h MTA → 24 h 2 nM dFdC 146.31 12.08 0.943 0.403     452.53 177.35   0.632 0.213 **
24 h MTA → 24 h 4 nM dFdC 130.60 29.92   0.858 0.461 *    1069.95 1035.22   0.373 0.190 **
24 h 2 nM dFdC → 24 h MTA 132.00 14.59 0.779 0.341 *    1322.54 833.14   0.546 0.237 **
24 h 4 nM dFdC → 24 h MTA 172.68 42.09   0.739 0.373 *    6076.56 3648.50   0.384 0.154 **
24 h dFdC → 24 h wash out 4.35 0.39        3.64 0.27     
24 h wash out → 24 h dFdC 5.87 0.17        5.30 0.20     
24 h dFdC + 24 h 50 nM MTA → 24 h wash out 4.25 0.37   1.141 0.858          
24 h dFdC + 24 h 100 nM MTA → 24 h wash out 5.82 0.68 1.201 0.843          
24 h dFdC + 24 h 200 nM MTA → 24 h wash out          7.48 1.04 1.112 0.972  
24 h dFdC + 24 h 500 nM MTA → 24 h wash out          19.40 11.06   1.167 0.967  
24 h dFdC → 24 h 50 nM MTA 3.83 0.07   1.073 0.872          
24 h dFdC → 24 h 100 nM MTA 3.61 0.20   1.179 1.071          
24 h dFdC → 24 h 200 nM MTA          4.90 1.79   0.873 0.924 *
24 h dFdC → 24 h 500 nM MTA          7.08 1.87   0.921 0.942  
24 h 50 nM MTA → 24 h dFdC 4.88 0.29 0.961 0.591          
24 h 100 nM MTA → 24 h dFdC 5.89 0.83   1.158 0.870          
24 h 200 nM MTA → 24 h dFdC          6.96 2.52   0.830 0.848 *
24 h 500 nM MTA → 24 h dFdC          14.81 10.54   0.838 0.806 *
1 h dFdC → 24 h wash out 478.76 149.90        533.46 197.64     
24 h wash out → 1 h dFdC 495.55 130.97        569.36 96.66     
1 h dFdC → 24 h 50 nM MTA 571.61 262.49   1.154 0.349          
1 h dFdC → 24 h 100 nM MTA 386.35 92.33   0.980 0.185          
1 h dFdC → 24 h 200 nM MTA          421.84 237.54   0.693 0.287 **
1 h dFdC → 24 h 500 nM MTA          407.32 187.49   0.570 0.265 **
24 h 50 nM MTA → 1 h dFdC 271.36 38.36   0.880 0.466 *         
24 h 100 nM MTA → 1 h dFdC 166.12 16.64 0.803 0.413 *         
24 h 200 nM MTA → 1 h dFdC          215.44 21.72 0.880 0.682 *
24 h 500 nM MTA → 1 h dFdC          217.14 24.80 0.681 0.494 **
  1. †: p < 0.05 vs. IC50 of the corresponding drug alone; *: moderate synergism (0.7<CI<0.9); **: synergism (CI<0.7).