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Table 1 DEF, CI, ID50, SF2 and % survival (representing the cytotoxic effect of treatment with MTA alone, 0 Gy) for irradiation (RT) given alone or in combination with MTA using different treatment schedules: 24 h MTA immediately followed by RT; RT immediately followed by 24 h MTA; 24 h MTA followed by different time intervals (24, 8, 4, 1, 0 h) and subsequent irradiation.

From: In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

 

Condition

DEF

CI

ID50

SF2

% survival

  

mean

SD

 

mean

SD

 

mean

SD

 

mean

SD

 

mean

SD

CAL-27

RT

      

1.94

0.47

 

48.37

9.31

 

100%

0%

 

24 h 50 nM MTA → RT

1.04

0.23

 

1.145

0.132

 

1.97

0.45

 

49.25

9.71

 

97%

11%

 

24 h 75 nM MTA → RT

1.01

0.10

 

1.260

0.270

 

1.94

0.54

 

47.75

7.53

 

70%

12%

 

24 h 100 nM MTA → RT

1.04

0.03

 

1.229

0.269

 

1.86

0.27

 

47.34

4.31

 

57%

4%

 

RT → 24 h 50 nM MTA

0.87

0.06

 

1.039

0.098

 

1.86

0.46

 

46.21

9.19

 

88%

4%

 

RT → 24 h 75 nM MTA

0.94

0.14

 

1.023

0.063

 

1.77

0.63

 

44.56

12.48

 

71%

8%

 

RT → 24 h 100 nM MTA

1.00

0.24

 

1.005

0.080

 

1.65

0.41

 

42.40

10.00

 

59%

12%

 

24 h 50 nM MTA → 24 h → RT

1.59

0.53

†

0.915

0.063

 

1.71

0.66

 

43.37

12.35

 

70%

21%

 

24 h 50 nM MTA → 8 h → RT

1.23

0.31

 

0.844

0.091

*

1.55

0.58

 

39.45

12.88

 

88%

4%

 

24 h 50 nM MTA → 4 h → RT

1.12

0.24

 

0.965

0.106

 

1.68

0.58

 

42.34

12.02

 

90%

6%

 

24 h 50 nM MTA → 1 h → RT

1.46

0.21

†

0.932

0.073

 

1.21

0.35

†

32.45

8.43

†

98%

4%

A549

RT

      

2.41

0.39

 

56.26

6.18

 

100%

0%

 

24 h 100 nM MTA → RT

1.29

0.25

 

0.698

0.079

**

1.77

0.36

 

45.39

7.15

 

87%

11%

 

24 h 200 nM MTA → RT

1.19

0.06

 

0.855

0.197

*

2.18

0.34

 

52.16

4.46

 

65%

12%

 

24 h 300 nM MTA → RT

0.97

0.23

 

0.887

0.294

*

2.84

1.03

 

57.46

8.70

 

52%

14%

 

24 h 500 nM MTA → RT

0.75

0.28

 

0.793

0.288

*

3.83

1.56

 

62.76

10.23

 

38%

13%

 

RT → 24 h 200 nM MTA

0.86

0.19

 

0.996

0.124

 

2.77

0.20

 

60.24

3.01

 

68%

19%

 

RT → 24 h 300 nM MTA

0.80

0.10

 

0.862

0.173

*

2.98

0.30

 

61.48

2.65

 

52%

16%

 

RT → 24 h 500 nM MTA

0.76

0.11

 

0.723

0.166

*

3.11

0.19

 

62.75

1.09

 

38%

15%

 

24 h 100 nM MTA → 24 h → RT

0.98

0.15

 

0.832

0.067

*

2.16

0.11

 

52.70

2.00

 

84%

16%

 

24 h 100 nM MTA → 8 h → RT

1.21

0.18

 

0.731

0.129

*

2.02

0.24

 

50.62

4.87

 

85%

9%

 

24 h 100 nM MTA → 4 h → RT

1.56

0.41

 

0.718

0.103

*

1.63

0.35

 

42.19

6.30

 

94%

10%

 

24 h 100 nM MTA → 1 h → RT

1.52

0.39

 

0.677

0.076

**

1.85

0.51

 

46.28

9.78

 

85%

11%

  1. †: p < 0.05 vs. 24 h incubation with the same concentration of MTA immediately followed by RT; *: moderate synergism (0.7<CI<0.9); **: synergism (CI<0.7).
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BMC Cancer

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