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Table 1 Summary of xenograft characteristics

From: Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

  Basal-like xenograft (MAS98.12) Luminal-like xenograft (MAS98.06)
  Primary tumor Xenograft Primary tumor Xenograft
Tumor grade Grade III IDC NA Grade III IDC NA
Lymph node status No metastasis NA Metastasis to 12 of 25 nodes NA
    No distant metastases  
Differentiation Poorly differentiated Poorly differentiated Well differentiated Poorly differentiated
Hormone receptor status ER-/PgR+** ER-/PgR- ER+/PgR+ ER+/PgR+
ERBB2 amplification* Negative Negative Negative Negative
Intrinsic molecular subtype Basal-like Basal-like Luminal-like Luminal-like
TP53 status Wildtype Mutated Mutated Mutated
Volume doubling time NA 1-2 days NA 7 days
Proliferation index (Ki67) Missing 28% Missing 35%
  1. Summary of characteristics related to genotype and phenotype of the xenograft models
  2. * Measured at the DNA level by array Comparative Genomic Hybridization (aCGH)
  3. ** The primary basal-like carcinoma had very weak cytoplasmic staining for PgR29.