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Table 1 Clinicopathological characteristics of 60 cases of NSCLC and TrkB expression by immunohistochemistry.

From: TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

Clinicopathological charateristics Cases (n = 60) Higher exression (n = 40) Lower expression (n = 20) P value
Tumor size and invasiveness     
   T1+T2 40 27 13 0.846
   T3+T4 20 13 7  
Histological type     
   Sq 25 15 10 0.355
   Ad 35 25 10  
Differentiation     
   well-moderate 44 28 16 0.409
   Poor 16 12 4  
Stage     
   I+II 34 19 15 0.043*
   III 26 21 5  
Lymph node status     
   + 30 24 6 0.028**
   - 30 16 14  
  1. TrkB expression: * = significant difference between early (I+II) and advanced (III) stage of NSCLCs; ** = significant difference between tumors with positive (+) and negative (-) nodes.