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Figure 4 | BMC Cancer

Figure 4

From: TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

Figure 4

Effects of Pyk2-siRNA on BDNF-induced cell invasion. Pyk2 knockdown cells had TrkB expression unaffected, while the activation of ERK promoted by BDNF treatment was largely reduced (A). In addition, the invasive number of Pyk2-siRNA transfected A549 cells was significantly decreased and less than those non-silencing and control cells (B). Original magnification, all ×400. The data are representative of three replicates.

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