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Figure 6 | BMC Cancer

Figure 6

From: LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

Figure 6

Cytotoxic effects of 5-FU and the expression of p-AKT by drug treatment in cells transfected with LMP2A siRNA. (A) LMP2A siRNA-silenced SNU-719 cells were subjected to RT-PCR for LMP2A in a time-dependent manner. (B) The inhibitory effects on cellular proliferation caused by 5-FU treatment were more pronounced in SNU-719 cells transfected with LMP2A siRNA than in cells transfected with the scrambled siRNA. (C) The expression of p-AKT was reduced further by 5-FU in cells transfected with LMP2A siRNA compared with in cells transfected with the scrambled siRNA (NC).

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