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Figure 2 | BMC Cancer

Figure 2

From: LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

Figure 2

Isobolograms showing the interaction between 5-FU and LY294002 in AGS and SNU-719 cells. Synergistic analysis of the interaction between 5-FU and LY294002 in AGS and SNU-719 gastric cancer cells. The interaction between 5-FU and LY294002 given on the schedule 5-FU → LY294002 is shown with an isobologram technique. The experimental isoeffect points are the concentrations (expressed relative to the 5-FU and LY294002 IC50 concentrations) of the two agents which, when combined, reduced cell viability by 50%. The data points above the diagonal line of the additive effects in the isobole suggest antagonism; those below the diagonal line suggest synergism. The isobologram analysis was based only on data obtained directly from actual experiments.

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