Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China

Table 4 The interactions of smoking, CYP1A 1 and GSTM1 variants in non-small cell lung cancer

Factor		Case(n)	Control(n)	Crude OR (95% CI)	Adjusted OR^a(95% CI)
CYP1A1 ^b	GSTM1 ^c
Aa+aa	-	43	39	1.63(0.81-3.31)	1.67(0.85-3.29)
	+	28	31	1.34(0.62-2.89)	1.55(0.74-3.25)
AA	-	52	40	1.93(0.97-3.84)	2.03(1.04-3.94)*
	+	27	40	1.00(reference)	1.00(reference)
Smoking habit	CYP1A1
Yes	Aa+aa	52	39	2.37(1.10-5.15)*	3.72(1.56-8.86)**
	AA	61	48	2.26(1.07-4.78)*	3.47(1.47-8.16)**
No	Aa+aa	19	31	1.09(0.45-2.66)	1.08(0.47-2.51)
	AA	18	32	1.00(reference)	1.00(reference)
Smoking habit	GSTM1
Yes	-	70	51	4.00(1.79-9.09)**	6.76(2.62-17.46)**
	+	43	36	3.48(1.48-8.33)**	5.93(2.26-15.59)**
No	-	25	28	2.60(1.03-6.67)*	2.84(1.17-6.92)*
	+	12	35	1.00(reference)	1.00(reference)

^a adjusted for sex, age, alcohol habit, tea habit, smoking habit and history of lung cancer in first-degree relatives.
^b AA = homogeneity wild genotype, Aa = heterogeneity genotype, aa = homogeneity variant genotype
^c - = null type, + = power
* p < 0.05 ** p < 0.01

ISSN: 1471-2407