Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients

BMC Cancer

Table 4 Correlations between lymphatic vessel density and clinicopathologic features in the laryngeal carcinoma series (N = 50).

PHARYNX	ILD			PLD			LVD			Lymphatic Invasion
Frequency	90% (45/50)			90% (45/50)			96% (48/50)			58% (29/50)
Mean (S.E.)	19.14 (1.97)			27.41 (2.57)			26.47 (1.92)
Score range	0-78.39			0-82.17			8.5 -79.34
	N	Mean (S.E)	p¥	N	Mean (S.E)	p¥	N	Mean range	p#	Absent	Present	Total	p*
Anatomic site
Hypopharynx	18	19.92 (3.48)	0.8600	18	30.87 (3.91)	0.3470	18	29.67	0.0810	12	6	18	0.0230
Oropharynx	31	19.18 (2.45)		31	25.70 (3.46)		31	22.29		9	22	31
Total	49			49			49			21	28	49
pT
T1-2	11	14.71 (3.53)	0.236	11	27.45 (3.12)	0.993	11	29.18	0.343	4	7	11	0.668
T3-4	39	20.39 (2.30)		39	27.39 (3.11)		39	24.46		17	22	39
Total	50			50			50			21	29	50
Nodal involvement
Free	9	16.30 (3.90)	0.3330	9	26.94 (7.77)	0.3450	9	27.50	0.6550	5	4	9	0.3630
Affected	41	19.77 (2.25)		41	27.51 (2.69)		41	25.06		16	25	41
Total	50			50			50			21	29	50
Tumour Stage
I-II	4	12.12 (7.01)	0.3720	4	19.05 (8.74)	0.3650	4	28.13	0.4280	4	0	4	0.0100
III-IV	41	19.60 (2.29)		41	28.57 (2.99)		41	22.50		14	27	41
Total	45			45			45			18	27	45
Recurrence
No	23	19.19 (2.37)	0.9140	23	26.41 (4.34)	0.7410	23	24.39	0.8480	9	14	23	0.6420
Yes	24	18.73 (3.45)		24	28.24 (3.43)		24	23.63		11	13	24
Total	47			47			47			20	27	47

ILD, Intratumoural Lymphatic Density; PLD, Peritumoural Lymphatic Density; LVD, Lymphatic Vessel Density
S.E., Standard Error
p^# (U Mann-Whitney); p^¥ (t Student); p* (chi square)
Frequencies (cases with lymph vessels), mean values and score ranges of ILD, PLD and LVD in pharyngeal population (N=50). Comparison of mean ILD, PLD and LVD values among different categories of clinico-pathological features. Distribution of tumours according to lymphatic invasion (LI) and clinicopathological features.

ISSN: 1471-2407