Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients

Table 3 Correlations between lymphatic vessel density and clinicopathologic features in the laryngeal carcinoma series (N = 54).

LARYNX	ILD			PLD			LVD)			Lymphatic Invasion
Frequency	57.41% (31/54)			55.56% (30/54)			87.04% (47/54)			28.30% (15/53)
Mean (S.E.)	10.59 (1.65)			18.47 (2.03)			18.98 (1.56)
Score range	0-41.56			0-60.45			0-44.71
	N	Mean range	p#	N	Mean (S.E)	p¥	N	Mean (S.E)	p¥	Absent	Present	Total	p*
Anatomic site
Glottis	30	23.45	0.028	30	15.22 (2.43)	0.073	30	16.14 (2.06)	0.042	23	6	29	0.176
Supraglottis	24	32.56		24	22.54 (3.30)		24	22.52 (2.24)		15	9	24
Total	54			54			54			38	15	53
pT
T1-2	28	22.05	0.006	28	15.95 (2.85)	0.2	28	15.98 (2.38)	0.044	25	3	28	0.003
T3-4	26	33.37		26	21.19 (2.86)		26	22.20 (1.84)		13	12	25
Total	54			54			54			38	15	53
Nodal involvement
Free	38	25.38	0.112	38	16.63 (2.23)	0.165	38	17.72 (1.81)	0.219	30	8	38	0.062
Affected	16	32.53		16	22.85 (4.27)		16	21.96 (3.03)		8	7	15
Total	54			54			54			38	15	53
Tumour Stage
I-II	24	20.92	0.004	24	13.95 (2.52)	0.045	24	15.05 (2.35)	0.023	20	4	24	0.073
III-IV	30	32.77		30	22.09 (2.92)		30	22.12 (1.94)		17	11	28
Total	54			54			54			37	15	52
Recurrence
No	43	28.35	0.169	43	17.02 (2.28)	0.218	43	18.60 (1.80)	0.685	29	13	42	0.492
Yes	10	21.20		10	23.55 (4.7)		10	20.28 (3.57)		8	2	10
Total	53			53			53			37	15	52

ILD, Intratumoural Lymphatic Density; PLD, Peritumoural Lymphatic Density; LVD, Lymphatic Vessel Density
S.E., Standard Error
p^# (U Mann-Whitney); p^¥ (t Student); p* (chi square)
Frequencies (cases with lymph vessels), mean values and score ranges of ILD, PLD and LVD in laryngeal carcinoma population (N=54). Comparison of mean ILD, PLD and LVD values among different categories of clinico-pathological features. Distribution of tumours according to lymphatic invasion (LI) and clinicopathological features.