Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients

BMC Cancer

Table 2 Correlations between lymphatic vessel density and clinicopathologic features in the HNSCC series (N = 104).

ALL CASES	ILD			PLD			LVD			Lymphatic Invasion
Frequency	75% (78/104)			80% (83/104)			94% (98/104)			42.72% (44/103)
Mean (S.E.)	14.8 (1.33)			22.0 (1.59)			22.3 (1.19)
Score range	0-78.4			0-82.2			0-79.3
	N	Mean range	p ^#	N	Mean (S.E)	p ^¥	N	Mean (S.E)	p ^¥	Absent	Present	Total	p*
Anatomic site
Pharynx	50	63.34	0.0004	50	27.41 (2.57)	0.0072	50	26.47 (1.92)	0.0029	21	29	50	0.002
Larynx	54	42.46		54	18.47 (2.03)		54	18.98 (1.56)		38	15	53
Total	104			104			104			59	44	103
pT
T1-2	39	39.09	0.0000	39	19.19 (2.47)	0.099	39	19.20 (2.03)	0.039	29	10	39	0.006
T3-4	65	60.55		65	24.91 (2.21)		65	24.61 (1.60)		30	34	64
Total	104			104			104			59	44	103
Nodal involvement
Free	47	42.44	0.0020	47	18.60 (2.37)	0.0230	47	19.34 (1.67)	0.0190	35	12	47	0.001
Affected	57	60.80		57	26.20 (2.27)		57	25.24 (1.82)		24	32	56
Total	104			104			104			59	44	103
Tumour Stage
I-II	28	32.98	0.0001	28	14.67 (2.44)	0.0010	28	16.89 (2.25)	0.0060	24	4	28	0.0000
III-IV	71	56.71		71	25.83 (2.14)		71	24.76 (1.57)		31	38	69
Total	99			99			99			55	42	97
Recurrence
No	66	50.98	0.8167	66	20.29 (2.17)	0.0729	66	21.15 (1.54)	0.1649	38	27	65	0.8050
Yes	34	49.57		34	26.86 (2.78)		34	25.04 (2.47)		19	15	34
Total	100			100			100			57	42	99

ILD, Intratumoural Lymphatic Density; PLD, Peritumoural Lymphatic Density; LVD, Lymphatic Vessel Density
S.E., Standard Error
p^# (U Mann-Whitney); p^¥ (t Student); p* (chi square)
Frequencies (cases with lymph vessels), mean values and score ranges of ILD, PLD and LVD in the whole series (N=104). Comparison of mean ILD, PLD and LVD values among different categories of clinico-pathological features. Distribution of tumours according to lymphatic invasion (LI) and clinicopathological features.

ISSN: 1471-2407