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Table 2 Correlations between lymphatic vessel density and clinicopathologic features in the HNSCC series (N = 104).

From: Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients

ALL CASES ILD PLD LVD Lymphatic Invasion
Frequency 75% (78/104) 80% (83/104) 94% (98/104) 42.72% (44/103)
Mean (S.E.) 14.8 (1.33) 22.0 (1.59) 22.3 (1.19)     
Score range 0-78.4 0-82.2 0-79.3     
  N Mean range p # N Mean (S.E) p ¥ N Mean (S.E) p ¥ Absent Present Total p*
Anatomic site              
Pharynx 50 63.34 0.0004 50 27.41 (2.57) 0.0072 50 26.47 (1.92) 0.0029 21 29 50 0.002
Larynx 54 42.46   54 18.47 (2.03)   54 18.98 (1.56)   38 15 53  
Total 104    104    104    59 44 103  
pT              
T1-2 39 39.09 0.0000 39 19.19 (2.47) 0.099 39 19.20 (2.03) 0.039 29 10 39 0.006
T3-4 65 60.55   65 24.91 (2.21)   65 24.61 (1.60)   30 34 64  
Total 104    104    104    59 44 103  
Nodal involvement              
Free 47 42.44 0.0020 47 18.60 (2.37) 0.0230 47 19.34 (1.67) 0.0190 35 12 47 0.001
Affected 57 60.80   57 26.20 (2.27)   57 25.24 (1.82)   24 32 56  
Total 104    104    104    59 44 103  
Tumour Stage              
I-II 28 32.98 0.0001 28 14.67 (2.44) 0.0010 28 16.89 (2.25) 0.0060 24 4 28 0.0000
III-IV 71 56.71   71 25.83 (2.14)   71 24.76 (1.57)   31 38 69  
Total 99    99    99    55 42 97  
Recurrence              
No 66 50.98 0.8167 66 20.29 (2.17) 0.0729 66 21.15 (1.54) 0.1649 38 27 65 0.8050
Yes 34 49.57   34 26.86 (2.78)   34 25.04 (2.47)   19 15 34  
Total 100    100    100    57 42 99  
  1. ILD, Intratumoural Lymphatic Density; PLD, Peritumoural Lymphatic Density; LVD, Lymphatic Vessel Density
  2. S.E., Standard Error
  3. p# (U Mann-Whitney); p¥ (t Student); p* (chi square)
  4. Frequencies (cases with lymph vessels), mean values and score ranges of ILD, PLD and LVD in the whole series (N=104). Comparison of mean ILD, PLD and LVD values among different categories of clinico-pathological features. Distribution of tumours according to lymphatic invasion (LI) and clinicopathological features.