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Table 1 Top signaling pathways for the 163 differentially expressed probe sets in MCF-7-14 and MDA-MB-231 cells.

From: Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

Pathway

Gene mapped to canonical pathways

JAK/STAT Signaling

PIK3R1, SOCS2

Xenobiotic Metabolism Signaling

ALDH3B2, MAOB, PIK3R1, UGT1A6

Axonal Guidance Signaling

BMP7, CFL2, CXCL12, PIK3R1, SEMA6D

TGF-β Signaling

BMP7, SMURF2

Acute Phase Response Signaling

PIK3R1, SOCS2, TCF3

Leukocyte Extravasation Signaling

CD44, CXCL12, PIK3R1

Neuregulin Signaling

ERRFI1, PIK3R1

IGF-1 Signaling

CYR61, PIK3R1

p53 Signaling

PIK3R1, RPRM

LPS/IL-1 Mediated Inhibition of RXR Function

ALDH3B2, MAOB, SLC27A2

Serotonin Receptor Signaling

MAOB

Notch Signaling

LFNG

Coagulation System

F12

Cell Cycle: G2/M DNA Damage Checkpoint Regulation

RPRM

EGF Signaling

PIK3R1

Wnt/β-catenin Signaling

CD44, TCF3

  1. Pathway analysis was performed on 163 probe sets (144 unique genes) up- or down-regulated >2-fold in both MCF-7-14 and MDA-MB-231 cells compared with MCF-7 cells (see Additional files 2 and 3) using IPA 5.0. Genes in bold are mapped to multiple top canonical pathways, and genes in bold italics are also mapped on the most significant functional network for the 163 probe sets (see also Figure 5C).