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Figure 1 | BMC Cancer

Figure 1

From: Mutations in the WTX- gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers

Figure 1

MSI-H colorectal tumors display frameshift mutations in the T 6 -microsatellite of the WTX -gene. (A) Genomic DNA from 632 patients with metastatic CRC (UICCIV) was analyzed for the presence of MSI-H with the help of the two monomorphic microsatellite markers BAT25 and BAT26. Shown are representative results from two CRCs with MSI-H (ID #1, #2) and one CRC with MSS (ID #42). (B) Two tumors of the 41 MSI-H cases of CRCs harbored frameshift mutations in the coding sequence of the T6-repeat of the WTX-gene resulting in the occurrence of a T5-repeat (ID #1 and #2) compared to only wild type T6-repeats in tumors with MSS CRCs (ID #3). Left: shown by FCE, right: shown by direct sequencing.

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