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Table 1 Combination indices calculated for imatinib and doxorubicin co-incubations in breast cancer cell lines

From: In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells

MDA MB 231

Drug

Combination Index Values at

Dm (nM)

m

r

 

ED 50

ED 75

ED 90

   

Combination (1:6000)

1.11214

1.01224

0.99765

0.39732

1.84658

0.96979

Doxorubicin

N/A

N/A

N/A

0.57999

1.15437

0.97662

Imatinib

N/A

N/A

N/A

5581.5821

2.92342

0.99784

MCF 7

Drug

Combination Index Values at

Dm (nM)

m

r

 

ED 50

ED 75

ED 90

   

Combination (1:1200)

1.32605

1.10981

0.95853

2.03607

1.48647

0.99769

Doxorubicin

N/A

N/A

N/A

4.56443

1.58527

0.96108

Imatinib

N/A

N/A

N/A

7487.20892

1.04304

0.98481

  1. ED 50 (effect dosis 50%), Dm (IC50) calculated, m (measures of sigmoidicity), r (correlation coefficient)
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BMC Cancer

ISSN: 1471-2407

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