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Table 1 Combination indices calculated for imatinib and doxorubicin co-incubations in breast cancer cell lines

From: In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells

MDA MB 231
Drug Combination Index Values at Dm (nM) m r
  ED 50 ED 75 ED 90    
Combination (1:6000) 1.11214 1.01224 0.99765 0.39732 1.84658 0.96979
Doxorubicin N/A N/A N/A 0.57999 1.15437 0.97662
Imatinib N/A N/A N/A 5581.5821 2.92342 0.99784
MCF 7
Drug Combination Index Values at Dm (nM) m r
  ED 50 ED 75 ED 90    
Combination (1:1200) 1.32605 1.10981 0.95853 2.03607 1.48647 0.99769
Doxorubicin N/A N/A N/A 4.56443 1.58527 0.96108
Imatinib N/A N/A N/A 7487.20892 1.04304 0.98481
  1. ED 50 (effect dosis 50%), Dm (IC50) calculated, m (measures of sigmoidicity), r (correlation coefficient)
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BMC Cancer

ISSN: 1471-2407

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