Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

Table 3 Pathway Express output summary.

		#Input genes in pathway			Corrected γ p-value
Pathway Name	# genes in pathway	TR	CEF NY72-4	CNR NY72-4	TR	CEF NY72-4	CNR NY72-4
ECM-receptor interaction	87	19	10	14	1.83E-11	3.37E-06	3.14E-07
Focal adhesion	195	26	14	19	6.87E-11	1.44E-06	3.47E-06
Phosphatidylinositol signaling system	77	3	1	3	7.71E-10	4.80E-11	1.71E-03
TGF-beta signaling pathway	84	10	7	N.D.	2.90E-06	2.12E-04	N.S.
Regulation of actin cytoskeleton	208	19	N.D.	11	1.27E-05	N.S.	5.03E-03
Small cell lung cancer	86	12	6	8	2.56E-05	9.19E-03	1.26E-02
Complement and coagulation cascades	69	4	2	N.D.	1.31E-03	2.15E-02	N.S.
Epithelial cell signaling in Helicobacter pylori infection	67	3	1	N.D.	2.80E-03	1.09E-05	N.S.
Leukocyte transendothelial migration	116	7	2	7	3.19E-03	1.73E-02	2.75E-02
Type II diabetes mellitus	44	4	1	N.D.	2.60E-02	2.85E-02	N.S.

Common pathways found to be dysregulated in the Transformation-Regulated (TR), CEF NY72-4 and CNR NY72-4 gene sets are shown. The number of genes in the pathway refers to the number of genes in the associated KEGG pathway (Kyoto Encyclopedia of Genes and Genomes, http://www.genome.jp/kegg/; [102]). Input genes refer to the number of differentially expressed genes that were found in that pathway. Corrected γ p-value is a measure of significance as calculated by Pathway Express. N.D. and N.S. indicate not determined and not significant (corrected γ p-value > 0.05) respectively.

ISSN: 1471-2407