Figure 3
From: Siah1 proteins enhance radiosensitivity of human breast cancer cells
Effect of Siah1 gain-of-function and silencing in IR-induced apoptosis. SKBR3 cells were transfected with indicated plasmids and irradiated with 0 and 4 Gy IR. Apoptosis was determined at 24 h after IR by FACS analysis. Columns, mean of three independent experiments; bars, SD; *, P < 0.05. Siah1 functions were silenced by siRNA. A control siRNA was used as well. Apoptosis was determined at 24 h after IR by FACS analysis. Columns, mean of three independent experiments; bars, SD; *, Siah1 siRNA vs. both untreated and control siRNA at 4 Gy, P < 0.05.