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Figure 4 | BMC Cancer

Figure 4

From: Residual γH2AX foci as an indication of lethal DNA lesions

Figure 4

Comparison between clonogenic fraction and fraction of cells lacking residual γH2AX foci for SiHa cells exposed to 8 drugs. With the exception of tirapazamine treatment that was conducted in suspension culture under anoxia, attached cells were exposed at 37°C in complete medium for either 30 min or 60 min (cisplatin, temozolomide). After rinsing, cells were allowed to recover for 24 hours before microscopic analysis of γH2AX foci and plating to measure clonogenic fraction. Combined results from 2-4 experiments are shown.

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