Skip to main content

Advertisement

Table 3 Association of CIMP with clinicopathological parameters

From: Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation

Variables Grading CIMP P*
   negative n (%) positive n (%)  
Age(Years) ≤50 8(22) 28(78)  
  > 50 10(34) 19(66) 0.272
Gender Female 2(33) 4(67)  
  Male 16(27) 43(73) 0.666
PVTT Negative 13(30) 31(70)  
  Positive 5(24) 16(76) 0.629
Preoperative AFP level(ng/ml) ≤400 14(40) 21(60)  
  > 400 4(13) 26(87) 0.017
Histopathologic grading Well+moderate 14(30) 33(70)  
  Poor 4(22) 14(78) 0.758
Tumor size(cm) ≤5 8(28) 21(72)  
  > 5 10(28) 26(72) 0.986
Tumor number Single 11(48) 12(52)  
  Multiple 7(17) 35(83) 0.007
Hangzhou criteria** Yes 12(43) 16(57)  
  No 6(16) 31(84) 0.017
  1. PVTT, portal vein tumor thrombi; AFP, alpha-fetoprotein
  2. ** Apart from the presence of macrovascular invasion, Hangzhou criteria are matched if total tumor diameter ≤ 8 cm, or if, total tumor diameter > 8 cm, with histopathologic grade I/II and AFP ≤ 400 ng/mL [38].
  3. *Pearson's Chi-square test or Fisher's exact test.