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Table 1 Genes investigated for methylation in HCC after LT

From: Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation

Gene

Chromosomal Locations

Function

References

SFRP1

8p12-11.1

Wnt signaling pathway antagonist

[30]

P16

9q21

Cell cycle regulation

[22]

SYK

9q22

Signal transduction

[12]

DAPK

9q34

Interferon-γ, TNF-α, and FAS-induced apoptosis

[25]

DKK1

10q11.1

Wnt signaling pathway antagonist

[31]

MGMT

10q26

DNA repair

[26]

GSTP1

11q13

Carcinogens and cytotoxic drug detoxification

[24]

TMS1

16p11-12

Apoptosis regulation

[25]

SOCS1

16p13.13

Regulator of cytokine signaling

[29]

CDH1

16q22

Cell adhesion

[23]

XAF1

17p13.2

Cell apoptosis

[27]

TIMP3

22q13.1

Tissue invasion and metastasis

[21]