Figure 1
Allele typing at hTERT -VNTR2-2 nd in cancer-free controls and patients with prostate cancer. (A) Electrophoretic patterns of PCR products of hTERT-VNTR2-2nd in controls. Four hTERT-VNTR2-2nd alleles and six haplotype patterns were detected in DNA from 421 cancer-free male controls. One new rare allele (39 copies of the repeat unit) and one previously reported rare allele (40 copies) identified in the control group are indicated with arrows. (B) Electrophoretic patterns of PCR products of hTERT-VNTR2-2nd in patients with prostate cancer. Seven hTERT-VNTR2-2nd alleles and eleven haplotype patterns were detected in DNA from 329 patients with prostate cancer. The three new rare alleles (28, 37, and 39 copies) and one previously reported rare allele (40 copies) identified in prostate patients are indicated with arrows. The 28- and 37-copy alleles were detected only in patients with prostate cancer. The first and last lanes correspond to a 1-kb marker (M).