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Table 1 Study subject characteristics

From: Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma

   # of Subjects
   Low PV Dose High PV Dose
Subjects   27 28
Gender Male 18 12
  Female 9 16
Mean Age at RT (range)   52 ± 6 (25-82) 51 ± 5 (26-77)
Glioma Grade Grade 3 8 9
  Grade 4 19 19
Racial-Ethnicity Caucasian 25 26
  Asian 2 2
Surgical Co-Intervention Biopsy-only 2 5
  Total Resection 16 6
  Subtotal Resection 9 17
Drug Co-intervention Temodar 27 27
  Avastin 5 9
  Other 8 3
Median Karnofsky Perf. Scale (range)   90% (70-100%) 90% (50-90%)
Mean RPA Classification # of RPA Class III 8 8
  # of RPA Class IV 11 8
  # of RPA Class V 8 12
MGMT Status Methylated 2 6
  Unmethylated 5 6
  Unknown 20 16
Tumor Localization Frontal 6 11
  Temporal 12 10
  Parietal 4 3
  Occipital 2 1
  Other 3 3
Mean Bilateral PV Dose   27 Gy ± 5 50 Gy ± 2
Median Ipsilateral PV Dose   46 Gy ± 15.5
Median Contralateral PV Dose   41 Gy ± 16.1
Median Ipsilateral HF Dose   49.9 Gy ± 16.3
Mean Total Prescription Dose (range)   52 Gy ± 4 (30-63) 57 Gy ± 2 (45-60)