|
Polymorphism
|
Genotypes
|
Cases n (%)
|
Controls n (%)
|
χ2
|
OR (95% CI) and p value
|
|---|
| |
TT
|
119 (62.3)
|
176 (60.5)
| | |
|
NOD1 (rs2075822)
|
TC
|
62 (32.5)
|
105 (36.1)
| |
1.188
|
| |
CC
|
10 (5.2)
|
10 (3.4)
|
p = 0.497
|
(0.774-1.823) p = 0.432
|
| |
TC+CC
|
72 (37.7)
|
115 (39.5)
| | |
| |
AA
|
104 (54.5)
|
152 (52.2)
| | |
|
NOD1 (rs2907749)
|
AG
|
68 (35.6)
|
118 (40.6)
| |
1.156
|
| |
GG
|
19 (9.9)
|
21 (7.2)
|
p = 0.392
|
(0.759-1.761) p = 0.499
|
| |
AG+GG
|
87 (45.5)
|
139 (47.8)
| | |
| |
CC
|
114 (59.7)
|
168 (57.7)
| | |
|
NOD1 (rs2907748)
|
CT
|
64 (33.5)
|
110 (37.8)
| |
1.156
|
| |
TT
|
13 (6.8)
|
13 (4.5)
|
p = 0.400
|
(0.755-1.769) p = 0.505
|
| |
CT+TT
|
77 (40.3)
|
123 (42.3)
| | |
| |
CC
|
182 (95.3)
|
282 (96.9)
| |
1.549
|
|
NOD2 (rs5743260)
|
CT
|
9 (4.7)
|
9 (3.1)
|
p = 0.359
|
(0.604-3.977) p = 0.363
|
| |
TT
|
0 (0.0)
|
0 (0.0)
| | |
| |
CC
|
178 (93.2)
|
263 (90.4)
| |
0.928
|
|
NOD2 (rs2066844)
|
CT
|
13 (6.8)
|
28 (9.6)
|
p = 0.278
|
(0.407-2.116) p = 0.859
|
| |
TT
|
0 (0.0)
|
0 (0.0)
| | |
| |
GG
|
187 (97.9)
|
282 (96.9)
| |
0.636
|
|
NOD2 (rs2066845)
|
GC
|
4 (2.1)
|
9 (3.1)
|
p = 0.508
|
(0.143-2.835) p = 0.553
|
| |
CC
|
0 (0.0)
|
0 (0.0)
| | |
| |
GG
|
177 (92.7)
|
275 (94.5)
| |
1.190
|
|
TLR2 (rs5743708)
|
GA
|
14 (7.3)
|
16 (5.5)
|
p = 0.416
|
(0.501-2.826) p = 0.694
|
| |
AA
|
0 (0.0)
|
0 (0.0)
| | |
| |
AA
|
163 (85.3)
|
258 (88.7)
| | |
|
TLR4 (rs4986790)
|
AG
|
25 (13.1)
|
31 (10.6)
| |
1.098
|
| |
GG
|
3 (1.6)
|
2 (0.7)
|
p = 0.449
|
(0.573-2.101) p = 0.778
|
| |
AG+GG
|
28 (14.7)
|
33 (11.3)
| | |
| |
TT
|
85 (44.5)
|
116 (39.9)
| | |
|
TLR9 (rs5743836)
|
TC
|
79 (41.4)
|
128 (44.0)
| |
0.781
|
| |
CC
|
27 (14.1)
|
47 (16.1)
|
p = 0.581
|
(0.511-1.195) p = 0.255
|
| |
TC+CC
|
106 (55.5)
|
175 (60.1)
| | |
| |
TT
|
138 (72.25)
|
187 (64.3)
| | |
|
TLR9 (rs187084)
|
TC
|
49 (25.65)
|
88 (30.2)
| |
0.675
|
| |
CC
|
4 (2.1)
|
16 (5.5)
|
p = 0.076
|
(0.428-1.064) p = 0.091
|
| |
TC+CC
|
53 (27.75)
|
104 (35.7)
| | |
- NB: Χ2 - Wild-type genotype versus heterozygous genotype versus homozygous variant genotype. Odds ratios for polymorphisms in NOD1, TLR4 and TLR9 were calculated as follows: Wild Type genotype compared to combination of heterozygous and homozygous variant genotypes. Odds ratios for polymorphisms in NOD2 and TLR2 were calculated as follows: Wild Type genotype compared to heterozygous genotype. All Odds Ratios were adjusted for age, BMI, diabetes, HBP, history of cancer, HT, smoking and alcohol use.
