Figure 3

Different AM network structure based on three different expression profiles . AM network structure alterations in three different comparisons among chemoresponse classes. A = chemoresistant patients vs controls; B = chemosensitive patients vs controls; C = chemoresistant vs chemosensitive patients. The fold changes are shown by gradients of node colours and sizes, according to the bar shown below the networks. The use of different sizes to show the expression values underlines as different expression profiles could notably alter the structure of a biological network: down regulated nodes have smaller sizes and, accordingly, minor molecular and functional effects on the network; on the other hand, up regulated nodes have larger sizes and a higher potential influence on network functions.