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Table 3 Relationship between EGFR protein expression and EGFR copy number, and mutation

From: Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas

IHC criteria Mutation   FISH  
  positive negative P value positive negative P value
First criteria       
   Positive (>10% tumor cells, ++ and +++) 65 26 0.008 45 46 0.012
   Negative 20 22   11 31  
Second criteria       
Positive (>10% tumor cells, any intensity) 76 38 0.105 51 63 0.132
Negative 9 10   5 14  
Third criteria Positive (H Score ≥ 100) 62 24 0.008 42 44 0.027
Negative(H Score < 100) 23 24   14 33  
  1. After Bonferroni correction, P < 0.025 was considered as significant. For using the first IHC criteria, IHC were significantly associated with mutation and FISH. For using the second IHC criteria, no significant association was found between IHC and mutation or FISH. For using the third IHC criteria, IHC was significantly associated with mutation, approached significant associated with FISH(P = 0.027,close to 0.025)