Figure 8
From: Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells
Morphology and cellular composition of tumors harvested at day 7 and day 14. (A) Fluorescent sections of tumors harvested at 7 days post-inoculation (red fluorescence - R2-T1AS cells; green fluorescence - G2B-10A cells). Left panel: R2-T1AS - tumors resulting from the injection of R2-T1AS cells alone, partially composed of solid tissue (arrowhead) and partially of necrotic areas (asterisk). Right panel: R2-T1AS/G2B-10A - tumors resulting from the injection of R2-T1AS cells mixed with G2B-10A. Majority (8 of 10) of tumors at day 7 had cystic structure. The lumen of the cyst (L) was filled with fluid and cellular debris, and surrounded by G2B-10A (green fluorescence) and R2-T1AS (red fluorescence) cells. (B) Fluorescent sections of tumors harvested at 14 days post-inoculation (red fluorescence - R2-T1AS cells; green fluorescence - G2B-10A cells). Both R2-T1AS and R2-T1AS/G2B-10A mixed tumors were composed of solid tissue formed by R2-T1AS cells (red fluorescence). Scale bars: 1 mm.