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Figure 7 | BMC Cancer

Figure 7

From: Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

Figure 7

G2B-10A benign mammary epithelial cells increase the tumorigenicity of R2-T1AS cells in vivo independent of benign-cell secreted factors. Growth of xenograft tumors in nude mice resulting from the injection of 4 × 106 G2B-10A cells alone (G2B-10A, green line, n = 4), 1 × 106 R2-T1AS cells alone (R2-T1AS, red line, n = 10), 1 × 106 R2-T1AS cells mixed with 4 × 106 G2B-10A cells (R2-T1AS/G2B-10A, blue line, n = 6) and 1 × 106 R2-T1AS mixed with 4 × 106 PFA-fixed G2B-10A cells (R2-T1AS/G2B-10A(PFA), gray line, n = 10). Tumor size was measured every 7 days using a digital caliper and tumor volume was calculated using the formula 0.52 × length × width2. Data shown are derived from 2 independent experiments. *p < 0.05.

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