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Table 1 Relation of MMP-3 genotype to clinical parameters and environmental factors among the OSMF, HNSCC and Control.

From: Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions

Characteristics

OSMF

(N = 101)

HNSCC

(N = 135)

Total Control

Control

(N = 126)

  

6A/6A genotype

5A/6A genotype

5A/5A genotype

p-value

6A/6A genotype

5A/6A genotype

5A/5A genotype

p-value

 

5A/5A genotype

6A/6A genotype

5A/6A genotype

(p-value)

Total

N = 236

74

(73.27%)

24

(23.76%)

3

(2.97%)

 

106

(78.5%)

23

(17.03%)

6

(4.44%)

 

126

2

(1.6%)

110

(87.3%)

14

(11.1%)

 

Gender

              

Male

192 (81.35)

62(83.8)

14(58.3)

2(66.6)

0.001

94 (88.67)

15(65.21)

5 (83.3)

0.01

105(83.3)

2 (100)

101 (91.8)

2(14.3)

0.01

Female

44 (18.64)

12(16.2)

10 (41.6)

1(33.3)

 

12 (11.32)

8(34.78)

1 (16.6)

 

21(16.7)

0

9(8.2)

12(85.7)

 

Age (Yrs)

              

Mean ± SD

43.4 ± 14.8

38.8 ± 14.5

37.6 ± 14.2

36 ± 8.5

0.671

42 ± 16.5

47 ± 10.8

41 ± 9.86

0.42

37.0 ± 12.8

17.5 ± 0.7

36.7 ± 12.4

38.8 ± 16

0.41

Tobacco with Areca nut

              

Chewer

215(91.1)

72(97.3)

23 (95.8)

2 (66.7)

0.02

98(92.45)

16(69.56)

4 (66.6)

0.003

85(67.5)

2(100)

71(64.5)

12(85.7)

0.12

Non Chewer

21(8.9)

2(2.7)

1 (4.2)

1 (33.3)

 

8(7.54)

7(30.43)

2 (33.3)

 

41(32.5)

0

39(35.5)

2(14.3)

 

Smoking status

              

Smoker

170(72.03)

42(56.7)

19(79.2)

3 (100)

0.077

88(83.01)

15(65.21)

4 (66.6)

0.037

51(40.5)

0

47(42.7)

4(28.6)

0.11

Non-smoker

66 (27.9)

32(43.3)

5 (20.8)

0

 

18(16.98)

8(34.78)

2 (33.3)

 

75(59.5)

2(100)

63(57.3)

10(71.4)

 

Alcohol Intake

              

Drinker

117(49.57)

22(29.7)

3 (12.5)

2 (66.7)

1.16

72(67.92)

14(60.86)

3 (50)

0..81

26(20.6)

0

25(22.7)

1(7.1)

0.24

Non Drinker

119(50.42)

52(70.3)

21 (87.5)

1 (33.3)

 

34(32.07)

9(39.1)

3 (50)

 

100(79.4)

2(100)

85(77.3)

13(92.9)

 

Location

              

Lip (lower &upper)

51 (21.61)

20(27)

7 (29.2)

1 (33.3)

 

19(17.92)

3(13.04)

1(16.67)

      

Tongue

38 (16.1)

10(13.5)

4 (16.7)

0

 

21(19.81)

2(8.69)

1 (16.1)

      

Right & left Cheek

32(13.56)

11(15)

3 (12.5)

1 (33.3)

0.81*

14(13.20)

3(13.04)

1 (16.1)

0.59*

-

-

-

-

-

Buccal mucosa

34 (14.41)

10(13.5)

4 (16.6)

0

 

15(14.15)

3(13.04)

1 (16.1)

      

Larynx/pharynx

81 (34.32)

23(31)

6(25)

1 (33.3)

 

37(34.91)

12(52.17)

2 (33.3)

      

OSMF Grade

              

(N = 101)

              

I-II

73 (72.28)

55 (74.3)

16 (66.6)

2 (66.6)

0.001

-

-

-

 

-

-

-

-

-

III-IV

28 (27.72)

19 (25.7)

8 (33.3)

1 (33.3)

          

HNSCC Grade

              

(N = 135)

              

T category

              

T1-3

37 (27.41)

    

21 (19.81)

14 (60.86)

2 (33.3)

      

T4

98 (72.59)

-

-

-

-

85 (80.18)

9 (39.13)

4 (66.6)

0.001

     

N category

              

N0

              

N1-3

42 (31.11)

93 (68.89)

-

-

-

-

30 (28.31)

76 (71.69)

6 (26.1)

17 (73.9)

1 (16.7)

5 (83.3)

0.814

     
  1. T & N categories [UICC TNM classification], Fisher's exact test & * Pearson's χ2 test were applied for statistical analysis.
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