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Table 1 Relation of MMP-3 genotype to clinical parameters and environmental factors among the OSMF, HNSCC and Control.

From: Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions

Characteristics OSMF
(N = 101)
HNSCC
(N = 135)
Total Control Control
(N = 126)
   6A/6A genotype 5A/6A genotype 5A/5A genotype p-value 6A/6A genotype 5A/6A genotype 5A/5A genotype p-value   5A/5A genotype 6A/6A genotype 5A/6A genotype (p-value)
Total N = 236 74
(73.27%)
24
(23.76%)
3
(2.97%)
  106
(78.5%)
23
(17.03%)
6
(4.44%)
  126 2
(1.6%)
110
(87.3%)
14
(11.1%)
 
Gender               
Male 192 (81.35) 62(83.8) 14(58.3) 2(66.6) 0.001 94 (88.67) 15(65.21) 5 (83.3) 0.01 105(83.3) 2 (100) 101 (91.8) 2(14.3) 0.01
Female 44 (18.64) 12(16.2) 10 (41.6) 1(33.3)   12 (11.32) 8(34.78) 1 (16.6)   21(16.7) 0 9(8.2) 12(85.7)  
Age (Yrs)               
Mean ± SD 43.4 ± 14.8 38.8 ± 14.5 37.6 ± 14.2 36 ± 8.5 0.671 42 ± 16.5 47 ± 10.8 41 ± 9.86 0.42 37.0 ± 12.8 17.5 ± 0.7 36.7 ± 12.4 38.8 ± 16 0.41
Tobacco with Areca nut               
Chewer 215(91.1) 72(97.3) 23 (95.8) 2 (66.7) 0.02 98(92.45) 16(69.56) 4 (66.6) 0.003 85(67.5) 2(100) 71(64.5) 12(85.7) 0.12
Non Chewer 21(8.9) 2(2.7) 1 (4.2) 1 (33.3)   8(7.54) 7(30.43) 2 (33.3)   41(32.5) 0 39(35.5) 2(14.3)  
Smoking status               
Smoker 170(72.03) 42(56.7) 19(79.2) 3 (100) 0.077 88(83.01) 15(65.21) 4 (66.6) 0.037 51(40.5) 0 47(42.7) 4(28.6) 0.11
Non-smoker 66 (27.9) 32(43.3) 5 (20.8) 0   18(16.98) 8(34.78) 2 (33.3)   75(59.5) 2(100) 63(57.3) 10(71.4)  
Alcohol Intake               
Drinker 117(49.57) 22(29.7) 3 (12.5) 2 (66.7) 1.16 72(67.92) 14(60.86) 3 (50) 0..81 26(20.6) 0 25(22.7) 1(7.1) 0.24
Non Drinker 119(50.42) 52(70.3) 21 (87.5) 1 (33.3)   34(32.07) 9(39.1) 3 (50)   100(79.4) 2(100) 85(77.3) 13(92.9)  
Location               
Lip (lower &upper) 51 (21.61) 20(27) 7 (29.2) 1 (33.3)   19(17.92) 3(13.04) 1(16.67)       
Tongue 38 (16.1) 10(13.5) 4 (16.7) 0   21(19.81) 2(8.69) 1 (16.1)       
Right & left Cheek 32(13.56) 11(15) 3 (12.5) 1 (33.3) 0.81* 14(13.20) 3(13.04) 1 (16.1) 0.59* - - - - -
Buccal mucosa 34 (14.41) 10(13.5) 4 (16.6) 0   15(14.15) 3(13.04) 1 (16.1)       
Larynx/pharynx 81 (34.32) 23(31) 6(25) 1 (33.3)   37(34.91) 12(52.17) 2 (33.3)       
OSMF Grade               
(N = 101)               
I-II 73 (72.28) 55 (74.3) 16 (66.6) 2 (66.6) 0.001 - - -   - - - - -
III-IV 28 (27.72) 19 (25.7) 8 (33.3) 1 (33.3)           
HNSCC Grade               
(N = 135)               
T category               
T1-3 37 (27.41)      21 (19.81) 14 (60.86) 2 (33.3)       
T4 98 (72.59) - - - - 85 (80.18) 9 (39.13) 4 (66.6) 0.001      
N category               
N0               
N1-3 42 (31.11)
93 (68.89)
- - - - 30 (28.31)
76 (71.69)
6 (26.1)
17 (73.9)
1 (16.7)
5 (83.3)
0.814      
  1. T & N categories [UICC TNM classification], Fisher's exact test & * Pearson's χ2 test were applied for statistical analysis.