TY - JOUR AU - Chun-zhi, Zhang AU - Lei, Han AU - An-ling, Zhang AU - Yan-chao, Fu AU - Xiao, Yue AU - Guang-xiu, Wang AU - Zhi-fan, Jia AU - Pei-yu, Pu AU - Qing-yu, Zhang AU - Chun-sheng, Kang PY - 2010 DA - 2010/07/12 TI - MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN JO - BMC Cancer SP - 367 VL - 10 IS - 1 AB - MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were discovered to induce cell growth and cell cycle progression via direct targeting of p27 and p57 in various human malignancies. However, the roles of miR-221 and miR-222 have not been reported in human gastric cancer. In this study, we examined the impact of miR-221 and miR-222 on human gastric cancer cells, and identified target genes for miR-221 and miR-222 that might mediate their biology. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-10-367 DO - 10.1186/1471-2407-10-367 ID - Chun-zhi2010 ER -