Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma

Table 3 Correlations among clinical features and SOD2 gene expression of primary TSCC^†

Age	Gender	pT stage	pN stage	C stage	Grade	Ki67^‡	SOD2^§
Patient cohort # 1 (n = 53)
Age	0.06	-0.07	0.08	0.03	na	0.16	0.14
Gender		0.09	-0.25	-0.07	na	0.01	0.20
pT stage			0.05	0.65 *	na	-0.18	0.49 *
pN stage				0.49 *	na	0.21	-0.28 *
C stage					na	-0.09	0.19
Grade						na	na
Ki67							-0.01
SOD2
Patient cohort #2 (n = 100)
Age	0.12	-0.05	-0.10	-0.01	-0.01	-0.01	-0.16
Gender		0.11	0.04	0.11	0.07	-0.05	-0.02
pT stage			0.42 *	0.77 *	-0.16	-0.01	0.04
pN stage				0.80 *	-0.05	0.09	-0.35 *
C stage					-0.07	0.05	-0.21 *
Grade						0.05	-0.30 *
Ki67							-0.28 *
SOD2

^† Spearman Correlation Coefficients.
^‡ The Ki67 index for Patient Cohort #1 was based on the relative mRNA level. The Ki67 index for Patient Cohort #2 was based on Immunohistochemical analysis.
^§ The expression levels of SOD2 for Patient Cohort #1 were based on the relative mRNA level. The expression levels of SOD2 for Patient Cohort #2 were generated from Immunohistochemical analysis.
* p < 0.05. The p values were computed using Fisher's transformed z-score test.
na: data not available.

ISSN: 1471-2407