Figure 5

Knockdown of fibronectin inhibits the metastatic ability of SPC-A-1sci cells in vivo. A, Representative images of histological inspection of one mouse lungs for the presence of microscopic lesions (Magnification, 50×; insert, 200×) four weeks after the tail vein injection with SPC-A-1sci cells stably expressing shRNA against negative control (shRNA-NC; Upper) or fibronecetin (shRNA-Fn1; Lower). B, Quantification of microscopic nodules in the lungs of each mouse expressed as mean ± SD of numbers obtained from eight animals in each group (shRNA-NC versus shRNA-Fn1); P = 9.27641E-07.