TY - JOUR AU - Zagouri, Flora AU - Sergentanis, Theodoros N. AU - Nonni, Afrodite AU - Papadimitriou, Christos A. AU - Michalopoulos, Nikolaos V. AU - Domeyer, Philip AU - Theodoropoulos, George AU - Lazaris, Andreas AU - Patsouris, Effstratios AU - Zogafos, Eleni AU - Pazaiti, Anastazia AU - Zografos, George C. PY - 2010 DA - 2010/07/05 TI - Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions JO - BMC Cancer SP - 353 VL - 10 IS - 1 AB - Hsp90 (heat shock protein90) is a chaperone protein essential for preserving and regulating the function of various cellular proteins. Elevated Hsp90 expression seems to be a trait of breast cancer and may be an integral part of the coping mechanisms that cancer cells exhibit vis-à-vis stress. This manuscript tries to examine the immunohistochemical expression of Hsp90 all along the continuum of breast ductal lesions encompassing ductal hyperplasia without atypia (DHWithoutA), atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-10-353 DO - 10.1186/1471-2407-10-353 ID - Zagouri2010 ER -