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Table 1 Clinicopathologic Features

From: Cyclin H expression is increased in GIST with very-highrisk of malignancy

Initial symptoms (multiple mentions possible)

 

n

% of 90

No clinical symptoms

 

25

28%

Pain

 

33

37%

GI bleeding

 

25

28%

Anemia

 

6

7%

Localization of primary tumour

 

n

% of 95

Stomach

 

58

61%

Small bowel

 

29

31%

   Jejunum

 

9

9%

   Ileum

 

17

18%

   Duodenum

 

3

3%

Colon

 

1

1%

Esophagus

 

2

2%

Others (EGIST, etc.)

 

5

5%

Second neoplasias

 

n

% of 95

Total

 

30

32%

  

n

% of 30

   Colorectal cancer

 

5

17%

   Prostate cancer

 

4

13%

   Breast cancer

 

3

10%

   Gastric cancer

 

3

10%

   Myometrial or cervical cancer

 

2

7%

   Renal or urothelian cancer

 

2

7%

   Pancreatic cancer

 

1

3%

   Others

 

10

33%

Histomorphology

 

n

% of 92

Spindle cell GIST

 

80

87%

Epithelioid/Mixed pattern

 

12

13%

   Mixed pattern

 

11

12%

   Epithelioid

 

1

1%

Risk of Malignancy (Fletcher et al.)

n (sto/smbo/ot)

n

% of 93

High risk

21/13/5

39

42%

Intermediate risk

13/5/1

19

20%

Low risk

14/7/0

21

23%

Very low risk

8/4/2

14

15%

  1. sto = stomach, smbo = small bowel, ot = others