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Table 1 Clinicopathologic Features

From: Cyclin H expression is increased in GIST with very-highrisk of malignancy

Initial symptoms (multiple mentions possible)   n % of 90
No clinical symptoms   25 28%
Pain   33 37%
GI bleeding   25 28%
Anemia   6 7%
Localization of primary tumour   n % of 95
Stomach   58 61%
Small bowel   29 31%
   Jejunum   9 9%
   Ileum   17 18%
   Duodenum   3 3%
Colon   1 1%
Esophagus   2 2%
Others (EGIST, etc.)   5 5%
Second neoplasias   n % of 95
Total   30 32%
   n % of 30
   Colorectal cancer   5 17%
   Prostate cancer   4 13%
   Breast cancer   3 10%
   Gastric cancer   3 10%
   Myometrial or cervical cancer   2 7%
   Renal or urothelian cancer   2 7%
   Pancreatic cancer   1 3%
   Others   10 33%
Histomorphology   n % of 92
Spindle cell GIST   80 87%
Epithelioid/Mixed pattern   12 13%
   Mixed pattern   11 12%
   Epithelioid   1 1%
Risk of Malignancy (Fletcher et al.) n (sto/smbo/ot) n % of 93
High risk 21/13/5 39 42%
Intermediate risk 13/5/1 19 20%
Low risk 14/7/0 21 23%
Very low risk 8/4/2 14 15%
  1. sto = stomach, smbo = small bowel, ot = others