Tumor-to-Organ Ratios | 12 hours | 24 hours | 48 hours |
|---|
Spleen | 0.00 | 0.03 | 0.02 |
Liver | 0.00 | 0.02 | 0.03 |
Kidney | 0.07 | 0.10 | 0.08 |
Lung | 0.06 | 0.05 | 0.11 |
Brain | 0.00 | 0.15 | 0.01 |
Heart | 0.01 | 0.01 | 0.00 |
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Note: Mice were injected with 100 μg of FITC-CPE peptide i.v. and fluorescence in tumor and normal tissues was measured using a whole-body optical imaging system at the indicated time points as described in the Methods. Data are presented as tumor-to-organ ratios calculated from the organ distribution of FITC-CPE peptide in SCID mice with OSPC-ARK-1 tumor xenografts (n = 3-5 animals). The autofluorescence background in mice that did not receive fluorescent compound was subtracted from the experimental values. Results are representative of 2 independent experiments showing similar results.
