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Table 2 Biodistribution of FITC-CPE peptide in SCID mice with OSPC-ARK-1 tumor xenografts

From: Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer

Tumor-to-Organ Ratios 12 hours 24 hours 48 hours
Spleen 0.00 0.03 0.02
Liver 0.00 0.02 0.03
Kidney 0.07 0.10 0.08
Lung 0.06 0.05 0.11
Brain 0.00 0.15 0.01
Heart 0.01 0.01 0.00
  1. Note: Mice were injected with 100 μg of FITC-CPE peptide i.v. and fluorescence in tumor and normal tissues was measured using a whole-body optical imaging system at the indicated time points as described in the Methods. Data are presented as tumor-to-organ ratios calculated from the organ distribution of FITC-CPE peptide in SCID mice with OSPC-ARK-1 tumor xenografts (n = 3-5 animals). The autofluorescence background in mice that did not receive fluorescent compound was subtracted from the experimental values. Results are representative of 2 independent experiments showing similar results.