Figure 4

FITC-conjugated CPE peptide distribution in OSPC-ARK-1 derived tumor xenografts in vivo. Briefly, SCID ovarian tumor-bearing mice were injected with 100 μg FITC-conjugated CPE peptide i.v. 6 weeks after OSPC-ARK-1 transplantation. Experimental and control mice were anesthetized and sacrificed 12, 24 and 48 hrs later and the abdominal wall was opened and tumor and normal organs analyzed by confocal microscopy. The representative distribution of FITC-conjugated CPE peptide at 12 hrs after injection in dissected tumor and normal organs including kidney, liver, spleen, lungs, brain and heart is shown. Note the strong fluorescence accumulation in the tumor when compared to the control organs.