Figure 1

Myc targets the Rel/NF-κB network in precancerous B cells and lymphomas. Hierarchical clustering of Rel/Nfkb family members, upstream kinases that regulate the NF-κB pathway, and selected control genes was performed using RNA prepared from B220⁺ splenic B cells from five weanling-age wild type mice (wt), from five Eμ-Myc transgenic mice (Eμ-Myc), and from thirteen Eμ-Myc lymphomas. Probe set signals were normalized to the mean across wt samples, and values of each individual sample are represented by a colour, with green corresponding to expression below, red corresponding to expression above, and black corresponding to expression equal to the wt mean expression.