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Table 5 Cox proportional hazard models of disease-free survival in patients with type of resection of R0 without or with multivariate adjustment*1

From: Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

Variable

Single-variate analyses

Multivariate analysis

 

Crude HR

95% CI

P value

AHR

95% CI

P value

25OHD, ng/mL

1.00

0.95-1.05

0.86

1.02

0.96-1.10

0.50

Age at surgery, years

1.01

0.98-1.04

0.64

1.00

0.96-1.04

0.95

Gender, female

0.69

0.31-1.56

0.38

0.68

0.25-1.86

0.46

Time period of surgery

      

May 2003 - December 2005

0.45

0.20-1.03

0.06

0.42

0.11-1.54

0.19

January 2006 - January 2008

reference

     

Stage

      

Stage I

0.00

-

-

0.00

-

-

Stage II

0.20

-

0.13

0.00

-

-

Stage III

0.68

0.18-0.56

0.71

0.00

0.00-0.00

< 0.001

Stage IV

Reference

  

Reference

  

Location of tumor

      

Proximal colon

1.14

0.49-2.64

0.56

0.69

0.23-2.03

0.50

Distal colon

0.43

0.12-1.55

0.20

0.57

0.13-2.40

0.44

Rectum

Reference

  

Reference

  

Adjuvant chemotherapy

4.49

1.71-11.75

0.002

0.68

0.18-2.64

0.58

Number of lymph nodes with metastasis*2

1.06

1.02-1.11

0.007

1.06

0.96-1.18

0.24

  1. *1: Multivariate hazard ratios (HR), 95% confidence intervals (CI), and P values were adjusted for age at diagnosis (years), gender, calendar month of blood sampling, cancer stage (I, II, III, and IV), residual tumor after surgery (R0, no residual tumor; R1, microscopic residual tumor; R2, macroscopic residual tumor), time period of surgery (between May 2003 and December 2005 or between January 2006 and January 2008), location of tumor, adjuvant chemotherapy, and number of lymph nodes with metastasis.
  2. *2: Lymph nodes were resected at surgery, and metastases in lymph nodes were confirmed pathologically.