|
Variable
|
Single-variate analyses
|
Multivariate analysis
|
|---|
| |
Crude HR
|
95% CI
|
P value
|
AHR
|
95% CI
|
P value
|
|---|
|
25OHD, ng/mL
|
0.98
|
0.93-1.02
|
0.31
|
0.91
|
0.84-0.99
|
0.027
|
|
Age at surgery, years
|
1.01
|
0.98-1.04
|
0.49
|
1.07
|
1.03-1.12
|
0.002
|
|
Gender, female
|
1.26
|
0.66-2.41
|
0.49
|
1.59
|
0.49-5.15
|
0.44
|
|
Time period of surgery
| | | | | | |
|
May 2003 - December 2005
|
0.94
|
0.48-1.85
|
0.87
|
0.41
|
0.13-1.27
|
0.12
|
|
January 2006 - January 2008
|
reference
| | | | | |
|
Stage
| | | | | | |
|
Stage I
|
0.00
|
-
|
-
|
0.00
|
-
|
-
|
|
Stage II
|
0.02
|
0.01-4.32
|
< 0.001
|
0.02
|
0.02-1.74
|
0.13
|
|
Stage III
|
0.13
|
0.07-0.27
|
< 0.001
|
1.13
|
0.16-7.85
|
0.90
|
|
Stage IV
|
Reference
| | |
Reference
| | |
|
Location of tumor
| | | | | | |
|
Proximal colon
|
1.07
|
0.52-2.22
|
0.86
|
1.42
|
0.55-3.68
|
0.47
|
|
Distal colon
|
0.45
|
0.15-1.34
|
0.15
|
0.42
|
0.09-1.94
|
0.27
|
|
Rectum
|
Reference
| | |
Reference
| | |
|
Type of resection, %
| | | | | | |
|
R0
|
0.04
|
0.02-0.09
|
< 0.001
|
0.01
|
0.00-0.11
|
< 0.001
|
|
R1
|
1.04
|
0.48-2.26
|
0.92
|
0.44
|
0.11-1.78
|
0.25
|
|
R2
|
Reference
| | |
Reference
| | |
|
Adjuvant chemotherapy
|
6.06
|
2.15-17.10
|
0.001
|
0.75
|
0.17-3.34
|
0.71
|
|
Number of lymph nodes with metastasis*2
|
1.08
|
1.05-1.11
|
< 0.001
|
1.09
|
1.02-1.16
|
0.016
|
- *1: Multivariate hazard ratios (HR), 95% confidence intervals (CI), and P values were adjusted for age at diagnosis (years), gender, calendar month of blood sampling, cancer stage (I, II, III, and IV), residual tumor after surgery (R0, no residual tumor; R1, microscopic residual tumor; R2, macroscopic residual tumor), time period of surgery (between May 2003 and December 2005 or between January 2006 and January 2008), location of tumor, adjuvant chemotherapy, and number of lymph nodes with metastasis.
- *2: Lymph nodes were resected at surgery, and metastases in lymph nodes were confirmed pathologically.
