Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

Table 2 Cox proportional hazard models of overall survival without or with multivariate adjustment*¹

Variable	Single-variate analyses			Multivariate analysis
	Crude HR	95% CI	P value	AHR	95% CI	P value
25OHD, ng/mL	0.98	0.93-1.02	0.31	0.91	0.84-0.99	0.027
Age at surgery, years	1.01	0.98-1.04	0.49	1.07	1.03-1.12	0.002
Gender, female	1.26	0.66-2.41	0.49	1.59	0.49-5.15	0.44
Time period of surgery
May 2003 - December 2005	0.94	0.48-1.85	0.87	0.41	0.13-1.27	0.12
January 2006 - January 2008	reference
Stage
Stage I	0.00	-	-	0.00	-	-
Stage II	0.02	0.01-4.32	< 0.001	0.02	0.02-1.74	0.13
Stage III	0.13	0.07-0.27	< 0.001	1.13	0.16-7.85	0.90
Stage IV	Reference			Reference
Location of tumor
Proximal colon	1.07	0.52-2.22	0.86	1.42	0.55-3.68	0.47
Distal colon	0.45	0.15-1.34	0.15	0.42	0.09-1.94	0.27
Rectum	Reference			Reference
Type of resection, %
R0	0.04	0.02-0.09	< 0.001	0.01	0.00-0.11	< 0.001
R1	1.04	0.48-2.26	0.92	0.44	0.11-1.78	0.25
R2	Reference			Reference
Adjuvant chemotherapy	6.06	2.15-17.10	0.001	0.75	0.17-3.34	0.71
Number of lymph nodes with metastasis*²	1.08	1.05-1.11	< 0.001	1.09	1.02-1.16	0.016

*1: Multivariate hazard ratios (HR), 95% confidence intervals (CI), and P values were adjusted for age at diagnosis (years), gender, calendar month of blood sampling, cancer stage (I, II, III, and IV), residual tumor after surgery (R0, no residual tumor; R1, microscopic residual tumor; R2, macroscopic residual tumor), time period of surgery (between May 2003 and December 2005 or between January 2006 and January 2008), location of tumor, adjuvant chemotherapy, and number of lymph nodes with metastasis.
*2: Lymph nodes were resected at surgery, and metastases in lymph nodes were confirmed pathologically.

ISSN: 1471-2407