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Table 1 Nomenclatures and sequences of PNAs

From: Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

Target (a)

PNA No.

Sequence (a)

5'-Int2

PNA2545

H-Acr-eg1- TCG GTG CTT ACC TGG-NH2

 

PNA2547

H-Acr-eg1-TGC TTA CCT GGA TCA-NH2

 

PNA2549

H-Acr-eg1-TTA CCT GGA TCA GCA-NH2

3'-Int2

PNA2551

H-Acr-eg1-TGT TGG TAT TGC ACA-NH2

 

PNA2553

H-Acr-eg1-TGG TAT TGC ACA TTT-NH2

 

PNA2555

H-Acr-eg1-TAT TGC ACA TTT GCC-NH2

 

PNA2406

H-Acr-eg1-TGC ACA TTT GCC TAC-NH2

 

PNA2557

H-Acr-eg1-ACA TTT GCC TAC AAG-NH2

 

PNA2559

H-Acr-eg1-TTT GCC TAC AAG GAA-NH2

 

PNA2561

H-Acr-eg1-GCC TAC AAG GAA AAA-NH2

3'-Int3

PNA2512

H-Acr-eg1-TTT GGT CTA ACC TAT -NH2

 

PNA2967

H-(D-Arg)8-TTT GGT CTA ACC TAT-NH2

 

PNA2968

H-(D-Arg)8-Lys(Deca)-TTT GGT CTA ACC TAT-NH2

PNA2406 mismatch

PNA2681

H-Acr-eg1-TGC AGA TTT CCC TAC-NH2

PNA2512 mismatch

PNA2733

H-Acr-eg1-TTT AGT CTA GCC TAT -NH2

  1. (a) Three PNAs are targeted to the 5'- splice site of intron2 of mdm2 pre-mRNA (5'-Int2). Seven PNAs are targeted to the 3'-splice site of intron2 (3'-Int2). PNA 2512 is targeted to the 3'- slice site of intron3 (3'-Int3). PNA2681 and PNA2733 are mismatch control PNAs for PNA2406 and PNA2512, respectively. Mismatches are indicated in bold. (b) The sequences of the PNAs (15-mer) are written from N-terminal to C-terminal-end. Acr and eg1 indicate 9-aminoacridinyl ligand and ethyleneglycol linker (8-amino-3,6-dioxaoctanoic acid), respectively.