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Table 1 ORGs Up-regulated 3-fold or Greater

From: Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

Probe Set1 Name1 Change1 Gene Description1 Biological Process2
1560019_at DLGAP1 14.6 discs large (Drosophila) homolog-associated protein 1 cell-cell signaling
205749_at CYP1A1 10.8 cytochrome p 450 family 1 electron transport
     drug metabolism
202672_s_at ATF3 9.4 activating transcription factor 3 transcription
209774_x_at CXCL2 8.6 chemokine (C-X-C motif) ligand 2 chemotaxis
206569_at IL-24 6.8 interleukin 24 apoptosis
205207_at IL-6 6.1 interleukin 6 acute phase response
     B cell differentiation
     cell cell signaling
     cell surface linked signal transduction
     humoral immune response
  TNFAIP3 4.2 tumor necrosis factor, alpha induced protein 3 anti-apoptosis
     apoptosis
     negative regulation of transcription, DNA dependent
204748_at PTGS2 (COX 2) 4.1 prostoglandin G/H synthase 2 cyclooxygenase activity
     regulation of inflammatory response
209383_at DDIT3 (GADD153) 3.7 DNA-damage inducible transcripts 3 cell cycle arrest
     transcription
     regulation of transcription, DNA dependent
     response to DNA damage stimulus
367_11 MAFF 3.5 v-maf parturition
     regulation of transcription, DNA dependent
     transcription from RNA polymerase II promoter
     transcription
205659_ at HDAC9 3.2 histone deacetylase 9 B cell differentiation
     histone deacetylation
     inflammatory response
     transcription
     regulation of transcription, DNA dependent
202149_at NEDD9 3.0 neural precursor cell expressed developmentally actin filament bundle formation
     cytoskeleton organization and biogenesis
205443_at SNAPC1 3.0 small nuclear RNA activating complex, polypeptide 1, 43 kDa regulation of transcription, DNA dependent
     transcription from RNA polymerase II promoter
     transcription from RNA polymerase III promoter
     transcription
  1. 1Affymetrix Data
  2. 2GeneInfoVis program [20, 22]