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Table 1 ORGs Up-regulated 3-fold or Greater

From: Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

Probe Set1

Name1

Change1

Gene Description1

Biological Process2

1560019_at

DLGAP1

14.6

discs large (Drosophila) homolog-associated protein 1

cell-cell signaling

205749_at

CYP1A1

10.8

cytochrome p 450 family 1

electron transport

    

drug metabolism

202672_s_at

ATF3

9.4

activating transcription factor 3

transcription

209774_x_at

CXCL2

8.6

chemokine (C-X-C motif) ligand 2

chemotaxis

206569_at

IL-24

6.8

interleukin 24

apoptosis

205207_at

IL-6

6.1

interleukin 6

acute phase response

    

B cell differentiation

    

cell cell signaling

    

cell surface linked signal transduction

    

humoral immune response

 

TNFAIP3

4.2

tumor necrosis factor, alpha induced protein 3

anti-apoptosis

    

apoptosis

    

negative regulation of transcription, DNA dependent

204748_at

PTGS2 (COX 2)

4.1

prostoglandin G/H synthase 2

cyclooxygenase activity

    

regulation of inflammatory response

209383_at

DDIT3 (GADD153)

3.7

DNA-damage inducible transcripts 3

cell cycle arrest

    

transcription

    

regulation of transcription, DNA dependent

    

response to DNA damage stimulus

367_11

MAFF

3.5

v-maf

parturition

    

regulation of transcription, DNA dependent

    

transcription from RNA polymerase II promoter

    

transcription

205659_ at

HDAC9

3.2

histone deacetylase 9

B cell differentiation

    

histone deacetylation

    

inflammatory response

    

transcription

    

regulation of transcription, DNA dependent

202149_at

NEDD9

3.0

neural precursor cell expressed developmentally

actin filament bundle formation

    

cytoskeleton organization and biogenesis

205443_at

SNAPC1

3.0

small nuclear RNA activating complex, polypeptide 1, 43 kDa

regulation of transcription, DNA dependent

    

transcription from RNA polymerase II promoter

    

transcription from RNA polymerase III promoter

    

transcription

  1. 1Affymetrix Data
  2. 2GeneInfoVis program [20, 22]