Figure 5
From: Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells
Angiogenesis assay. A blood vessel construction image was overlaid with a grid image of the same size, and neovascularity was evaluated as the total number of intersections between the vessel and grid in the entire plate (A). The shown photographs are representative data of invasion assay of T98G. The density of neovasculature decreased as the concentration of MMI-166 increased (B). The neovasculature induced by glioma cells decreased as the concentration of MMI-166 increased in all three glioma cell lines (C). Statistically significant differences were observed between the MMI-166-treated samples and the control (non-treated) (*p < 0.0001).