Figure 3

Sub clinical cardiotoxicity defined as reduction LVEF in RCTs comparing different treatment regimens. The open diamond represents the pooled Peto Odds Ratio and 95% CI for treatment comparisons 1-4, and relative risk (RR) with 95% CI for comparisons 5-7. I-squared represents the proportion of variability between studies in excess of that expected due to chance, and p = probability that the differences between study estimates are due to chance.