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Table 3 Multivariate analysis of factors associated with distant metastasis-free survival in the 8-gene Score, the 70-Gene Signature and the Recurrence Score

From: An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

  8-Gene Score
  HR CI 95% p value
Tumor size 1.31 0.52 - 3.3 0.55
Nodal status 2,87 1.38 - 6.01 0.005
Grade
(2 vs.1)
(3 vs. 1)
0.60
1.42
0.11 - 3.16
0.28 - 7.15
0.227
0.555
0.665
8-gene Score 15.61 4.41 - 55.17 <0.001
  70-Gene Signature
  HR CI 95% p value
Tumor size 1.4 0.57 - 3.42 0.46
Nodal status 2.70 1.30 - 5.62 0.008
Grade
(2 vs.1)
(3 vs. 1)
0.82
2.349
0.160 - 4.181
0.473 - 11.672
0.113
0.810
0.297
70-Gene Signature 3.505 1.33 - 9.23 0.011
  Recurrence Score
  HR CI 95% p value
Tumor size * 1.17 0.48 - 2.82 0.72
Nodal status ** 2.49 1.20 - 5.16 0.014
Grade
(2 vs1)
(3 vs 1)
0.68
2.26
0.13 - 3.45
0.49 - 10.40
0.043
0.644
0.292
Recurrence Score
(Interm. vs. Low risk)
(High vs. Low risk)
4.46
8.18
0.78 - 25.33
1.76 - 37.86
0.021
0.091
0.007
  1. *Tumor size: >2 cm vs. ≤2 cm. **Nodal status: positive (1-3) vs negative.