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Table 1 Clinico-pathologic characteristics and MED28 expression in individuals with breast cancer

From: Elevated MED28 expression predicts poor outcome in women with breast cancer

   MED28 Expression Dichotomized   Continuous
   Low High P-Value ± σ P-Value
All Invasive Patients N = 88 N = 66 N = 22   0.946 ± 0.668  
Age at Diagnosis   = 55.2 = 55.9 0.8926a ρ = 0.024b 0.8195b
   Median (Range) 53 (30 - 89) 53.5 (30 - 89) 52 (36 - 89)    
   25th to 75th Quartile 45 - 66 45 - 74 45 - 77.2    
Clinical Stage   = 1.712 = 2.318 0.0035a   0.0052b
   I 33 28 5 0.0028d 0.782 ± 0.721 0.0090e
   II 36 30 6   0.918 ± 0.541  
   III 17 7 10   1.312 ± 0.708  
   IV 2 1 1   1.075 ± 0.813  
Tumor Grade   = 2.063 = 2.455 0.0678a   0.0061b
   1 23 21 2 0.0882d 0.598 ± 0.429 0.0099f
   2 25 17 8   1.009 ± 0.698  
   3 37 25 12   1.112 ± 0.726  
   Unknown 3 3 0    
Lymph Node Metastasis     0.1004c   0.0303a
   Absent 38 32 6   0.833 ± 0.775  
   Present 34 22 12   1.083 ± 0.612  
   Unknown 16 12 4    
Tumor Size (cm)   = 2.175 = 2.955 0.0283a ρ = 0.303b 0.0060b
   Median (Range) 2.2 (0.1 - 9.0) 2.0 (0.1 - 7.25) 2.5 (0.5 - 9.0)    
   25th to 75th Quartile 1.18 - 3.00 1.0 - 2.5 1.7 - 4.0    
Lymphovascular Invasion     0.0720c   0.0201a
   Absent 55 45 10   0.812 ± 0.599  
   Present 32 20 12   1.177 ± 0.734  
   Unknown 1 1 0    
ER Status     0.2514c   0.0489a
   Positive 62 48 14   0.866 ± 0.594  
   Negative 21 13 8   1.271 ± 0.822  
   Unknown 5 5 0    
PR Status     0.0640c   0.1828a
   Positive 58 47 11   0.864 ± 0.562  
   Negative 28 17 11   1.142 ± 0.838  
   Unknown 2 2 0    
HER-2/neu Status     0.0335c   0.1022a
   Positive 19 10 9   1.181 ± 0.644  
   Negative 61 49 12   0.923 ± 0.661  
   Unknown 8 7 1    
  1. (a) Mann-Whitney, (b) Spearman Correlation, (c) Fisher's Exact Test, (d) Chi-Square Test, (e) Mann-Whitney with clinical stage dichotomized as stage I&II vs. III&IV, and (f) Kruskal-Wallis Test. Cases that were uninformative for a given variable were removed from statistical analysis. No lymphadenectomies were performed for these patients.