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Table 2 Association between 8q24 Sequence Variants and Prostate Cancer Risk.

From: 8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

8q24

Cases

Controls

ORcrude

ORadj

P-Valuecrude ‡‡

P-Trend

 

n (%)

n (%)

(95% CI)†

(95% CI) ††

  

rs6983561

      

AA

48 (25.8)

171 (33.6)

1.00

1.00

0.0783

0.0246

AC

88 (47.3)

232 (45.7)

1.35 (0.90 - 2.02)

1.78 (1.10 - 2.89)

0.1436

 

CC

50 (26.9)

105 (20.7)

1.70 (1.07 - 2.70)

1.99 (1.15 - 3.46)

0.0258

 

AC + CC

138 (74.2)

337 (66.3)

1.46 (1.00 - 2.13)

1. 85 (1.18 - 2.91)

0.0486

 

rs1447295

      

GG

86 (45.5)

237 (45.3)

1.00

1.00

0.8742

0.8451

GT

77 (40.7)

221 (42.3)

0.96 (0.67 - 1.37)

0.82 (0.55 - 1.26)

0.8239

 

TT

26 (13.8)

65 (12.4)

1.10 (0.66 - 1.85)

0.92 (0.49 - 1.70)

0.7121

 

GT + TT

103 (54.5)

286 (54.7)

0.99 (0.71 - 1.39)

0.86 (0.45 - 1.61)

0.9647

 

rs4242384

      

AA

122 (63.2)

383 (73.1)

1.00

1.00

0.0135

0.0515

AC

65 (33.7)

120 (22.9)

1.70 (1.18 - 2.45)

1.50 (0.99 - 2.28)

0.0043

 

CC

6 (3.1)

21 (4.0)

0.90 (0.35 - 2.27)

0.91 (0.32 - 2.53)

0.8188

 

AC + CC

71 (36.8)

141 (26.9)

1.58 (1.11 - 2.25)

1.41 (0.95 - 2.11)

0.0101

 

rs4242382

      

GG

85 (40.0)

244 (48.1)

1.00

1.00

0.6002

 

GA

80 (41.5)

191 (37.7)

1.20 (0.84 - 1.72)

1.12 (0.74 - 1.69)

0.3148

0.4655

AA

28 (14.5)

72 (14.2)

1.12 (0.68 - 1.84)

1.05 (0.60 - 1.86)

0.6671

 

GA + AA

108 (56.0)

326 (51.9)

1.18 (0.85 - 1.65)

1.01 (0.75 - 1.62)

0.3332

 

rs11934905

      

GG

173 (94.5)

500 (96.0)

1.00

1.00

0.4161

---

GA + AA

10 (5.5)

21 (4.0)

1.38 (0.64 - 2.98)

1.83 (0.54 - 6.24)

  

rs16901979

      

GG

45 (23.4)

188 (36.7)

1.00

1.00

0.001

0.0002

GT

97 (50.5)

237 (46.3)

1.71 (1.14 - 2.56)

2.28 (1.42 - 3.69)

0.0089

 

TT

50 (26.1)

87 (17.0)

2.40 (1.49 - 3.87)

3.02 (1.72 - 5.31)

0.0003

 

GT + TT

147 (76.6)

324 (63.3)

1.90 (1.30 - 2.77)

2.49 (1.58 - 3.92)

0.0001

 

rs10090154

      

GG

124 (65.6)

357 (70.7)

1.00

1.00

0.2878

0.2878

GA

59 (31.2)

131 (25.9)

1.30 (0.90 - 1.88)

1.11 (0.72 - 1.69)

0.1676

 

AA

6 (3.2)

17 (3.4)

1.02 (0.39 - 2.64)

0.88 (0.30 - 2.57)

0.9737

 

GA + AA

65 (34.4)

148 (29.3)

1.26 (0.89 - 1.81)

1.08 (0.72 - 1.63)

0.1914

 
  1. †Associations were determined using multivariate LR models to estimate the risk of developing PCA.
  2. ††Risk estimates adjusted for age (continuous variable) and West African Ancestry (continuous variable).
  3. ‡‡Differences in the frequency of variant and referent genotypes between cases and controls were determined using the chi-square test of association and a significance level of 0.05.
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BMC Cancer

ISSN: 1471-2407

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