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Table 2 Association between 8q24 Sequence Variants and Prostate Cancer Risk.

From: 8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

8q24 Cases Controls ORcrude ORadj P-Valuecrude ‡‡ P-Trend
  n (%) n (%) (95% CI) (95% CI) ††   
rs6983561       
AA 48 (25.8) 171 (33.6) 1.00 1.00 0.0783 0.0246
AC 88 (47.3) 232 (45.7) 1.35 (0.90 - 2.02) 1.78 (1.10 - 2.89) 0.1436  
CC 50 (26.9) 105 (20.7) 1.70 (1.07 - 2.70) 1.99 (1.15 - 3.46) 0.0258  
AC + CC 138 (74.2) 337 (66.3) 1.46 (1.00 - 2.13) 1. 85 (1.18 - 2.91) 0.0486  
rs1447295       
GG 86 (45.5) 237 (45.3) 1.00 1.00 0.8742 0.8451
GT 77 (40.7) 221 (42.3) 0.96 (0.67 - 1.37) 0.82 (0.55 - 1.26) 0.8239  
TT 26 (13.8) 65 (12.4) 1.10 (0.66 - 1.85) 0.92 (0.49 - 1.70) 0.7121  
GT + TT 103 (54.5) 286 (54.7) 0.99 (0.71 - 1.39) 0.86 (0.45 - 1.61) 0.9647  
rs4242384       
AA 122 (63.2) 383 (73.1) 1.00 1.00 0.0135 0.0515
AC 65 (33.7) 120 (22.9) 1.70 (1.18 - 2.45) 1.50 (0.99 - 2.28) 0.0043  
CC 6 (3.1) 21 (4.0) 0.90 (0.35 - 2.27) 0.91 (0.32 - 2.53) 0.8188  
AC + CC 71 (36.8) 141 (26.9) 1.58 (1.11 - 2.25) 1.41 (0.95 - 2.11) 0.0101  
rs4242382       
GG 85 (40.0) 244 (48.1) 1.00 1.00 0.6002  
GA 80 (41.5) 191 (37.7) 1.20 (0.84 - 1.72) 1.12 (0.74 - 1.69) 0.3148 0.4655
AA 28 (14.5) 72 (14.2) 1.12 (0.68 - 1.84) 1.05 (0.60 - 1.86) 0.6671  
GA + AA 108 (56.0) 326 (51.9) 1.18 (0.85 - 1.65) 1.01 (0.75 - 1.62) 0.3332  
rs11934905       
GG 173 (94.5) 500 (96.0) 1.00 1.00 0.4161 ---
GA + AA 10 (5.5) 21 (4.0) 1.38 (0.64 - 2.98) 1.83 (0.54 - 6.24)   
rs16901979       
GG 45 (23.4) 188 (36.7) 1.00 1.00 0.001 0.0002
GT 97 (50.5) 237 (46.3) 1.71 (1.14 - 2.56) 2.28 (1.42 - 3.69) 0.0089  
TT 50 (26.1) 87 (17.0) 2.40 (1.49 - 3.87) 3.02 (1.72 - 5.31) 0.0003  
GT + TT 147 (76.6) 324 (63.3) 1.90 (1.30 - 2.77) 2.49 (1.58 - 3.92) 0.0001  
rs10090154       
GG 124 (65.6) 357 (70.7) 1.00 1.00 0.2878 0.2878
GA 59 (31.2) 131 (25.9) 1.30 (0.90 - 1.88) 1.11 (0.72 - 1.69) 0.1676  
AA 6 (3.2) 17 (3.4) 1.02 (0.39 - 2.64) 0.88 (0.30 - 2.57) 0.9737  
GA + AA 65 (34.4) 148 (29.3) 1.26 (0.89 - 1.81) 1.08 (0.72 - 1.63) 0.1914  
  1. Associations were determined using multivariate LR models to estimate the risk of developing PCA.
  2. ††Risk estimates adjusted for age (continuous variable) and West African Ancestry (continuous variable).
  3. ‡‡Differences in the frequency of variant and referent genotypes between cases and controls were determined using the chi-square test of association and a significance level of 0.05.