Table 2 Functional annotation analysis of differentially expressed genes
From: Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
Biological processes affected by over-expression of wild type and truncated HMGA2 | |
|---|---|
Vascular development (4 of 66 up-regulated genes) | p = 0.039 |
Response to wounding (17 of 139 down-regulated genes) | p < 0.001 |
Signal transduction (40/139) | p < 0.001 |
Chemotaxis (11/139) | p < 0.001 |
Cytosolic calcium ion homeostasis (5/139) | p < 0.001 |
Phosphate transport (5/139) | p = 0.0017 |
Regulation of cell proliferation (11/139) | p = 0.0033 |
Cell migration (8/139) | p = 0.0057 |
Cell recognition (3/139) | p = 0.027 |
Epithelial cell differentiation (3/139) | p = 0.026 |
Wound healing (4/139) | p = 0.042 |
Biological processes affected by over-expression of wild type HMGA2 | |
Multi-cellular organismal development (20 of 84 up-regulated genes) | p = 0.0011 |
Response to hormone stimulus (4/84) | p = 0.0034 |
Regulation of signal transduction (7/84) | p = 0.022 |
Pyridine nucleotide biosynthetic process (3 of 99 down-regulated genes) | p = 0.0017 |
Steroid hormone receptor activity (3/99) | p = 0.0032 |
Negative regulation of transcription factor activity (3/99) | p = 0.0034 |
Positive regulation of transcription (7/99) | p = 0.0065 |
Response to external stimulus (8/99) | p = 0.042 |
Biological processes affected by over-expression of truncated HMGA2 | |
Regulation of transcription (61 of 258 up-regulated genes) | p < 0.001 |
Intracellular protein transport across a membrane (6/258) | p = 0.0032 |
Membrane organization and biogenesis (11/258) | p = 0.011 |
Ras protein signaling transduction (9/258) | p = 0.031 |
Regulation of cytoskeleton organization and biogenesis (4/258) | p = 0.042 |
Antigen processing and presentation (10 of 239 down-regulated genes) | p < 0.001 |
Multi-cellular organismal development (41/239) | p = 0.0021 |
Cell adhesion (16/239) | p = 0.019 |
Eye morphogenesis (3/239) | p = 0.035 |