Table 1 Identification of genes most differentially expressed between the parental cell line and the over-expressing cell lines
From: Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
| Â | Â | Changes in HMGA2WTcells | Changes in HMGA2trunc cells | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Rank | Gene | Description | MA | qPCR | Rel. to EGFP* | Gene | Description | MA | qPCR | Rel. to EGFP* |
a) | 1 | CXCL6 | Chemokine (C-X-C motif) ligand 6 | -8.4 | -6.7 | -2.2 | CXCL6 | Chemokine (C-X-C motif) ligand 6 | -9.0 | -6.3 | -2.2 |
| Â | 2 | IL8 | Interleukin 8 | -7.5 | -7.1 | -6.4 | HLA-DRA | Major histocompatibility complex class II antigen DRA | -8.7 | -8.1 | -7.2 |
| Â | 3 | CD24 | CD24 molecule | -7.1 | Â | Â | HLA-DPA1 | Major histocompatibility complex class II antigen DPA1 | -8.0 | -6.8 | -5.5 |
| Â | 4 | C13orf33 | Chromosome 13 open reading frame 33 | -6.5 | Â | Â | ChGn | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase | -6.5 | Â | Â |
| Â | 5 | PTGES | Prostaglandin E synthase | -6.3 | Â | Â | PKIB | cAMP-dependent protein kinase inhibitor 2 | -6,4 | -4.9 | -5.0 |
| Â | 6 | ChGn | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase | -5.6 | Â | Â | IFI44L | Interferon-induced protein 44-like | -6.2 | Â | Â |
| Â | 7 | IL6 | Interleukin 6 | -5.5 | Â | Â | LAMA4 | Laminin alpha chain | -6.2 | Â | Â |
| Â | 8 | PDE4D | cAMP-specific phosphodiesterase 4D | -5.2 | Â | Â | SLC38A5 | Solute carrier family 38, member 5 | -6.0 | Â | Â |
| Â | 9 | IL1RN | Interleukin 1 receptor antagonist | -5.1 | -4.4 | -3.0 | PTPRN2 | Protein tyrosine phosphatise, receptor type, N2 | -5.5 | Â | Â |
| Â | 10 | CES1 | Carboxylesterase 1 | -5.1 | Â | Â | C13orf33 | Chromosome 13 open reading frame 33 | -5.4 | Â | Â |
| Â | 11 | KIAA1644 | KIAA1644 protein | -5.0 | -3.4 | -1.7 | n/a | Similar to Wnt-1 inducible signalling pathway protein 1 | -5.4 | Â | Â |
| Â | 12 | SAMSN1 | SH3-SAM adaptor protein | -4.8 | Â | Â | IL1B | Interleukin1 beta | -5.3 | -4.3 | -2.2 |
| Â | 13 | SERPIND1 | Serpin peptidase inhibitor, clade D, member 1 | -4.7 | Â | Â | F2RL1 | Coagulation factor II receptor-like 1 | -5.2 | Â | Â |
| Â | 14 | FAM5C | Familiy with sequence similarity 5,member C | -4.4 | Â | Â | CD74 | CD74 antigen-associated invariant chain | -5.2 | -5.4 | -4.3 |
| Â | 15 | n/a | Transcribed sequence FLJ 26764 | -4.3 | Â | Â | IL1RN | Interleukin 1 receptor antagonist | -5.2 | -5.2 | -3.8 |
b) | 1 | ZBED2 | Zinc finger BED domain-containing protein 2 | 5.3 | 4.5 | Â | n/a | transcribed sequence FLJ33010 | 6.7 | Â | Â |
| Â | 2 | SHROOM2 | Shroom family member 2 | 4.6 | Â | Â | CXCL12 | Chemokine (C-X-C motif) ligand 12 | 6.4 | 2.7 | 2.0 |
| Â | 3 | FGF13 | Fibroblast growth factor 13 | 4.5 | 4.6 | 5.6 | PRSS7 | Serine protease 7 | 6.0 | Â | Â |
| Â | 4 | BAI3 | Brain-specific angiogenesis inhibitor 3 | 4.5 | 4.4 | 5.4 | SULT1B1 | Sulfotransferase 1B1 | 5.8 | Â | Â |
| Â | 5 | PLXNA4 | Plexin A4 | 4.4 | Â | Â | SSX1 | Synovial sarcoma, X breakpoint 1 | 4.9 | 9.6 | 10.2 |
| Â | 6 | LCP1 | Lymphocyte cytosolic protein 1 | 4.1 | 3.9 | 2.1 | MMP3 | Matrix metalloproteinase-3 | 4.7 | Â | Â |
| Â | 7 | C20orf197 | Chromosome 20 open reading frame 197 | 4.0 | Â | Â | CYB5R2 | Cytochrome b5 reductase 2 | 4.5 | Â | Â |
| Â | 8 | G0S2 | G0/S switch 2 | 3.7 | 5.6 | 5.4 | KISS1 | KiSS-1 metastasis-supressor | 4.5 | Â | Â |
| Â | 9 | HDAC9 | Histone deacetylase 9 | 3.7 | 1.5 | Â | EDN1 | Endothelin 1 | 4.5 | Â | Â |
| Â | 10 | SIGLEC15 | Sialic acid binding Ig-like lectin 15 | 3.7 | Â | Â | SYNE1 | Synaptic nuclear envelope protein 1 | 4.4 | Â | Â |
| Â | 11 | HCLS1 | Hematopoietic cell-specific Lyn substrate 1 | 3.6 | 2.5 | 3.6 | HAPLN1 | Hyaluronan and proteoglycan link protein 1 | 4.4 | Â | Â |
| Â | 12 | LOC646340 | similar to Ankyrin repeat domain-containing protein 18A | 3.6 | Â | Â | n/a | transcribed sequence FLJ35091 | 4.4 | Â | Â |
| Â | 13 | GATA3 | GATA binding protein 3 | 3.5 | 3.6 | >10 | n/a | Similar to TATA box-binding protein-associated factor 1B | 4.3 | Â | Â |
| Â | 14 | SH3BGRL2 | SH3 domain binding glutamic acid-rich protein like 2 | 3.5 | Â | Â | BAI3 | Brain-specific angiogenesis inhibitor 3 | 4.2 | 4.6 | 5.6 |
| Â | 15 | PDE4B | cAMP-specific phospodiesterase 4B | 3.5 | Â | Â | n/a | Similar to cytochrome c oxidase I | 4.1 | Â | Â |