Table 1 Particular aspects of the clinical diagnosis for each control and HB-19 treated RET mice
Treatment | Remarks in mice before autopsy (< Day 300) | Diagnosis at autopsy (Day 300) | |||
|---|---|---|---|---|---|
Mice | Regression | Death | Cutaneous tumor location and size (mm) | Distant metastasis | |
Control | 1 | under eye 4, nose 3.1, under ear 4.9, back 6.7, 2.8 and 2.9, thigh 5.9 | Mediastinal | ||
2 | cheek 4.9, eye 6.2, under ear 5.4, 6.2, 7 and 5.7, back 6.3 and 4.2, around genitals 3.8 and 4.7 | None | |||
3 | cheek 3.3, under ear 6.7, around eye 6.3, back ear 3.5, back 3.2, thigh 5.1 | Retroperitoneal | |||
4 | under eye 6.7 and 2.3, cheek 4.1 and 3, upper ear 2.8, under ear 3.4 and 5.6, leg 4.9 and 4.3, genitals 4 | Retroperitoneal | |||
5 | under eye 11, 4 leg neighboring nodules 13.9 | Visceral | |||
6 | upper eye 6.3, under eye 2.6, between ears 5.4 | Retroperitoneal | |||
7 | cheek 2.9, nose 4.3, under ear 3.8, ear 4.7 | Retroperitoneal | |||
8 | cheek 3.1, under eye 2.7 | None | |||
9 | under ear 2.5, between eyes 3.8, under eye 6.3 and 3, leg 6.8, genitals 5.5, tail base 5.9 | Retroperitoneal | |||
10 | cheek 5.6, 5.1, 3.4 and 3.7, under eye 7.4, leg 4.7, thigh 11.3 | None | |||
11 | back ears 4.9, back 2.8, 1.9, 6.4, 3.5 and 2.2 | Retroperitonel | |||
HB-19 treated | 1 | under eye 6, cheek 3.5, around left eye 7.7, between ears 5, genitals 8, foot 9.2, tail 3.6 | Visceral | ||
2 | under eye and thigh | cheek 5.2 and 3, under eye 5, 3 nodules on the left cheek < 1, between ears 8.2, thigh 8.2, foot 7.9 | Visceral | ||
3 | cheek 2.5, under ear 5.7, back 9.6, 5.5 and 3.2, thigh 6 | Lung | |||
4 | Tumor free mouse | None | |||
5 | dead D219* | Tumor free mouse at day 219 | None | ||
6 | Tumor free mouse | None | |||
7 | cheek 1.4, under eye 3.9, back ears 6.4 | None | |||
8 | under eye 3.9, under ear 4.7, back 1.5, tail base 2.3 | None | |||
9 | around eye 6.7 | None | |||